Volume 26, Issue 116 (7-2018)                   J Adv Med Biomed Res 2018, 26(116): 100-110 | Back to browse issues page

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Mansoriyan M, Torabzadeh Khorasani P, Ramezani M. Effect of Fluoxetine on Ovarian and Oviduct Tissue in Female Mature Balb/C Mice. J Adv Med Biomed Res 2018; 26 (116) :100-110
URL: http://journal.zums.ac.ir/article-1-5092-en.html
Effect of Fluoxetine on Ovarian and Oviduct Tissue in Female Mature Balb/C Mice
Mahsa Mansoriyan1 , Parvin Torabzadeh Khorasani *2 , Mina Ramezani3
1- Dept. of Biology, Karaj Branch, Islamic Azad University, Alborz, Iran
2- Dept. of Biology, Karaj Branch, Islamic Azad University, Alborz, Iran , p.torabzadeh@gmail.com
3- Dept.of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (161390 Views)

Background and Objective: Use of antidepressants such as fluoxetine, which is widely used worldwide and easily accessible to the public, causes complications such as temporary or permanent infertility. The present study was conducted to investigate the effects of fluoxetine on the ovaries and oviducts of mature female Balb/C mice.
Materials and Methods: In this study after determining the appropriate dose of fluoxetine, it was injected intraperitoneally (IP) for 30 days into 75 adult Balb/C mice with doses of 15 mg/kg (group 1), 20 mg /kg (group 2), 25 mg /kg (group 3), control group (non-injection) and sham (distilled water injection). ANOVA analysis and Duncan test were used to compare the means with significant levels being considered (P<0.05) and (P <0.001).
Results: During macroscopic examination, significant ovary weight decrease was observed in all three doses
(P <0.001) and in microscopic studies, reduction of the small and large diameter, number of graph follicles and corpus luteum were observed (P <0.05 and P <0.001 respectively). Meanwhile, an increase in the number of degenerative follicles and damaged zona pellucidas was significant (P <0.001 and P <0.05), and oviduct diameter was significantly higher than the control group (P <0.05).
Conclusion: It can generally be concluded that fluoxetine has a damaging effect on ovarian and oviduct tissue of mice.

Keywords: Fluoxetine, ovary, oviduct, follicle, mice
Full-Text [PDF 3064 kb]   (157547 Downloads)    
Type of Study: Clinical Trials |
Received: 2018/03/3 | Accepted: 2018/03/3 | Published: 2018/03/3
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