دوشنبه 18 فروردین 1404
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دوره ۳۲، شماره ۱۵۳ - ( ۵-۱۴۰۳ )
جلد ۳۲ شماره ۱۵۳ صفحات ۲۶۸-۲۶۰ |
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Ethics code: IR.SSU.MEDICINE.REC.1400.118
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Soleymani Salehabadi H, Soltani H, Amel Shahbaz A, Binesh F, Dehghan A, Bashiri H, et al . The Correlation between Renal Color Doppler Indices and Pathological and Laboratory Parameters in Patients with Lupus Nephritis. J Adv Med Biomed Res 2024; 32 (153) :260-268
URL: http://journal.zums.ac.ir/article-1-7498-fa.html
URL: http://journal.zums.ac.ir/article-1-7498-fa.html
The Correlation between Renal Color Doppler Indices and Pathological and Laboratory Parameters in Patients with Lupus Nephritis. Journal of Advances in Medical and Biomedical Research. ۱۴۰۳; ۳۲ (۱۵۳) :۲۶۰-۲۶۸
چکیده: (۲۵۴ مشاهده)
Background & Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting 20–50 per 100,000 people. This study aimed to assess the relationship between ultrasound indices and pathological and laboratory parameters in patients with lupus nephritis (LN).
Materials & Methods: This cross-sectional, descriptive-diagnostic study was conducted on 32 patients and 32 healthy individuals. Sonographic indices, renal biopsy results, and laboratory parameters were assessed. A Receiver Operating Characteristic (ROC) curve was used to predict sensitivity and specificity. P-value <0.05 was considered significant.
Results: The mean GFR and anti-dsDNA levels in patients were 77.4±30.2 ml/min/1.73m² and 2.8±4.4 IU/ml, respectively. Abnormal C3, abnormal C4, and positive aPL were observed in 17 (60.7%), 9 (32.1%), and 8 (28.5%) patients, respectively. In terms of biopsy classification, most patients were in class II (32.1%). The mean biopsy activity index (bxAI) and biopsy chronicity index (bxCI) were 12.11±7.8 and 4.39±3.60, respectively. There was no significant association between the resistive index (RI) and pathological or laboratory parameters (P>0.05). However, a significant association was found between peak systolic velocity (PSV) and end-diastolic velocity (EDV) with GFR, and a negative association
between PSV and EDV with aPL and bxCI in patients with LN(P<0.05). The sensitivity and specificity of the anti-dsDNA test for detecting bxCI using a cut-off value of 0.245 were 84% and 96%, respectively (area under the ROC curve = 0.92).
Conclusion: This study found no association between RI and pathological or laboratory parameters. However, there was a negative association between PSV and EDV with the degree of chronic kidney damage in patients with LN. Anti-dsDNA appears to be a useful predictor of long-term renal outcomes in these patients.
Materials & Methods: This cross-sectional, descriptive-diagnostic study was conducted on 32 patients and 32 healthy individuals. Sonographic indices, renal biopsy results, and laboratory parameters were assessed. A Receiver Operating Characteristic (ROC) curve was used to predict sensitivity and specificity. P-value <0.05 was considered significant.
Results: The mean GFR and anti-dsDNA levels in patients were 77.4±30.2 ml/min/1.73m² and 2.8±4.4 IU/ml, respectively. Abnormal C3, abnormal C4, and positive aPL were observed in 17 (60.7%), 9 (32.1%), and 8 (28.5%) patients, respectively. In terms of biopsy classification, most patients were in class II (32.1%). The mean biopsy activity index (bxAI) and biopsy chronicity index (bxCI) were 12.11±7.8 and 4.39±3.60, respectively. There was no significant association between the resistive index (RI) and pathological or laboratory parameters (P>0.05). However, a significant association was found between peak systolic velocity (PSV) and end-diastolic velocity (EDV) with GFR, and a negative association
between PSV and EDV with aPL and bxCI in patients with LN(P<0.05). The sensitivity and specificity of the anti-dsDNA test for detecting bxCI using a cut-off value of 0.245 were 84% and 96%, respectively (area under the ROC curve = 0.92).
Conclusion: This study found no association between RI and pathological or laboratory parameters. However, there was a negative association between PSV and EDV with the degree of chronic kidney damage in patients with LN. Anti-dsDNA appears to be a useful predictor of long-term renal outcomes in these patients.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Clinical Medicine
دریافت: 1403/2/15 | پذیرش: 1403/8/12 | انتشار: 1403/5/30
دریافت: 1403/2/15 | پذیرش: 1403/8/12 | انتشار: 1403/5/30
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