Sun, Jun 8, 2025
[Archive]
Volume 32, Issue 153 (July & August 2024)
J Adv Med Biomed Res 2024, 32(153): 260-268 |
Back to browse issues page
Ethics code: IR.SSU.MEDICINE.REC.1400.118
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Soleymani Salehabadi H, Soltani H, Amel Shahbaz A, Binesh F, Dehghan A, Bashiri H, et al . The Correlation between Renal Color Doppler Indices and Pathological and Laboratory Parameters in Patients with Lupus Nephritis. J Adv Med Biomed Res 2024; 32 (153) :260-268
URL: http://journal.zums.ac.ir/article-1-7498-en.html
URL: http://journal.zums.ac.ir/article-1-7498-en.html
Hossein Soleymani Salehabadi1 
, Hamidreza Soltani *2 , Amirpasha Amel Shahbaz1 , Fariba Binesh3 , Ali Dehghan1 , Hamidreza Bashiri3 , Mohamadbagher Owlia3 , Roya Hemayati3
, Hamidreza Soltani *2 , Amirpasha Amel Shahbaz1 , Fariba Binesh3 , Ali Dehghan1 , Hamidreza Bashiri3 , Mohamadbagher Owlia3 , Roya Hemayati3
1- Shahid Sadoughi Uni
2- Shahid Sadoughi Uni ,hr.soltan@yahoo.com
3- Shahid sadoughi
2- Shahid Sadoughi Uni ,
3- Shahid sadoughi
Abstract: (342 Views)
Background & Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting 20–50 per 100,000 people. This study aimed to assess the relationship between ultrasound indices and pathological and laboratory parameters in patients with lupus nephritis (LN).
Materials & Methods: This cross-sectional, descriptive-diagnostic study was conducted on 32 patients and 32 healthy individuals. Sonographic indices, renal biopsy results, and laboratory parameters were assessed. A Receiver Operating Characteristic (ROC) curve was used to predict sensitivity and specificity. P-value <0.05 was considered significant.
Results: The mean GFR and anti-dsDNA levels in patients were 77.4±30.2 ml/min/1.73m² and 2.8±4.4 IU/ml, respectively. Abnormal C3, abnormal C4, and positive aPL were observed in 17 (60.7%), 9 (32.1%), and 8 (28.5%) patients, respectively. In terms of biopsy classification, most patients were in class II (32.1%). The mean biopsy activity index (bxAI) and biopsy chronicity index (bxCI) were 12.11±7.8 and 4.39±3.60, respectively. There was no significant association between the resistive index (RI) and pathological or laboratory parameters (P>0.05). However, a significant association was found between peak systolic velocity (PSV) and end-diastolic velocity (EDV) with GFR, and a negative association
between PSV and EDV with aPL and bxCI in patients with LN(P<0.05). The sensitivity and specificity of the anti-dsDNA test for detecting bxCI using a cut-off value of 0.245 were 84% and 96%, respectively (area under the ROC curve = 0.92).
Conclusion: This study found no association between RI and pathological or laboratory parameters. However, there was a negative association between PSV and EDV with the degree of chronic kidney damage in patients with LN. Anti-dsDNA appears to be a useful predictor of long-term renal outcomes in these patients.
Materials & Methods: This cross-sectional, descriptive-diagnostic study was conducted on 32 patients and 32 healthy individuals. Sonographic indices, renal biopsy results, and laboratory parameters were assessed. A Receiver Operating Characteristic (ROC) curve was used to predict sensitivity and specificity. P-value <0.05 was considered significant.
Results: The mean GFR and anti-dsDNA levels in patients were 77.4±30.2 ml/min/1.73m² and 2.8±4.4 IU/ml, respectively. Abnormal C3, abnormal C4, and positive aPL were observed in 17 (60.7%), 9 (32.1%), and 8 (28.5%) patients, respectively. In terms of biopsy classification, most patients were in class II (32.1%). The mean biopsy activity index (bxAI) and biopsy chronicity index (bxCI) were 12.11±7.8 and 4.39±3.60, respectively. There was no significant association between the resistive index (RI) and pathological or laboratory parameters (P>0.05). However, a significant association was found between peak systolic velocity (PSV) and end-diastolic velocity (EDV) with GFR, and a negative association
between PSV and EDV with aPL and bxCI in patients with LN(P<0.05). The sensitivity and specificity of the anti-dsDNA test for detecting bxCI using a cut-off value of 0.245 were 84% and 96%, respectively (area under the ROC curve = 0.92).
Conclusion: This study found no association between RI and pathological or laboratory parameters. However, there was a negative association between PSV and EDV with the degree of chronic kidney damage in patients with LN. Anti-dsDNA appears to be a useful predictor of long-term renal outcomes in these patients.
Keywords: Laboratory Parameters, Lupus Nephritis, Pathological Parameters, Resistive Index, Ultrasonography
Type of Study: Original Research Article |
Subject:
Clinical Medicine
Received: 2024/05/4 | Accepted: 2024/11/2 | Published: 2024/08/20
Received: 2024/05/4 | Accepted: 2024/11/2 | Published: 2024/08/20
References
1. Abd Elsamea MH, Badr A, Ibrahim H, Talaat E. Renal arterial resistive index as a noninvasive biomarker of disease activity in lupus nephritis patients. Egipt Roumatol. 2022; 4:239-244. [DOI:10.1016/j.ejr.2022.01.001]
2. Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P. et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine. 2003; 82(5):299-308. [DOI:10.1097/01.md.0000091181.93122.55] [PMID]
3. Gheita TA, Abualfadl E, Abousehly OS. Adult systemic lupus erythematosus in Egypt: the nation-wide spectrum of 3661 patients and world-wide standpoint. Lupus. 2021; 30(9):1526-35. [DOI:10.1177/09612033211014253] [PMID]
4. Mohamed DF, Hassan SM, Shedid NH. Juvenile lupus: different clinical and serological presentations compared to adult lupus in Egypt. Egyp Reumatol. 2018; 40(1):55-8. [DOI:10.1016/j.ejr.2017.04.004]
5. Lipsky P. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nature Immunol. 2001; 2: 764-6. [DOI:10.1038/ni0901-764] [PMID]
6. Zhang Z. Efficacy and safety of mesenchymal stem cell transplantation in the treatment of autoimmune diseases (Rheumatoid Arthritis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, and ankylosing spondylitis): A systematic review and meta-analysis of randomized controlled trial. Stem Cell Int. 2022; 1-20. [DOI:10.1155/2022/9463314] [PMID] [PMCID]
7. Herrada A EN. Iruretagoyena M, Innate Immune Cells' Contribution to Systemic Lupus Erythematosus. Front Immunol. 2019; 10: 772-775. [DOI:10.3389/fimmu.2019.00772] [PMID] [PMCID]
8. Parks Ch SESA, Barbhaiya M. Understanding the role of environmental factors in the development of systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2017; 31(3): 306-320. [DOI:10.1016/j.berh.2017.09.005] [PMID] [PMCID]
9. Farah R. Characteristics and histological types of lupus nephritis in a Jordanian tertiary medical center. Biomed Res Int. 2019: 7087461-464. [DOI:10.1155/2019/7087461] [PMID] [PMCID]
10. Tektonidou M. Dasgupta A, Ward MM. Risk of end-stage renal disease in patients with lupus nephritis, 1971-2015. Arterits Rhumatol. 2016; 1971-2015. [DOI:10.1002/art.39594] [PMID] [PMCID]
11. Gao J NA, Shih G, Goldstein M, Kapur S, Wang J, Min R. Intrarenal color doppler sonography: A window to vascular complications of renal transplant. J Ultrasound Med 2007; 26: 1403-1405. [DOI:10.7863/jum.2007.26.10.1403] [PMID]
12. Davoodi M. Investigating complications of needle biopsy of intrathoracic lesions with CT scan guidance Investigation of complications of needle biopsy of intrathoracic lesions with CT scan guidance. AMHSR. 2014; 8 (1): 28-32.
13. Conti F CF, Gigante A. Ultrasonographic evaluation of renal resistive index in patients with lupus nephritis: correlation with histologic findings. Ultrasound Med Biol. 2014; 40(11): 2573-2580. [DOI:10.1016/j.ultrasmedbio.2014.06.016] [PMID]
14. Hajipour R, Ghadamzadeh M. Comparison the diagnostic value of doppler ultrasonography to biopsy, in evaluation of post-transplant complications and kidney function. JOT. 2022;1-9. [DOI:10.14302/issn.2576-9359.jot-22-4303]
15. El-Wakil EK, Maharem E. Mahena M. Hasab.Renal arterial resistive index in Egyptian patients with lupus nephritis: Correlation with disease activity and biopsy parameters. Int Res J Med Med Sci. 2018; 6 (1): 18-34. [DOI:10.30918/IRJMMS.61.17.035]
16. Chen Q HF, Feng X, Zhengmao Lu.Correlation of Doppler parameters with renal pathology: A study of 992 patients. Expr Ther Med. 2013; 439-442. [DOI:10.3892/etm.2013.1442] [PMID] [PMCID]
17. Platt JF, Ellis JH. Lupus nephritis: predictive value of conventional and Doppler US and comparison with serologic and biopsy parameters. Radiology. 1997; 203(1):82-6. [DOI:10.1148/radiology.203.1.9122420] [PMID]
18. Goldblum JR, Lamps LW, McKenney JK. Rosai and Ackerman's Surgical Pathology E-Book. Elsevier Health Sciences. 2017; 25.
19. Chen L. Modification of diet in renal disease (MDRD) study and CKD epidemiology collaboration (CKD-EPI) Equations for Taiwanese Adults. Plos One. 2014; 1-9. [DOI:10.1371/journal.pone.0099645] [PMID] [PMCID]
20. Kasem T.Resistivity Index (RI): A Fast and Reliable Indicator of Lupus Nephritis Severity. Med J cario univ. 2020; 68(21):1-9
21. Chen Q. Correlation of Doppler parameters with renal pathology: A study of 992 patients. Expriment therapeutic Med. 2014; 7: 439-443. [DOI:10.3892/etm.2013.1442] [PMID] [PMCID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright Policy
