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1- , amir_saheb2000@yahoo.com
Abstract: (673 Views)
Background:Bacterial vaginosis (BV) is one of the most frequent vaginal infections and has been linked to unfavorable reproductive outcomes. Vitamin D is known to play a key role in regulating immune function, and its deficiency has been proposed as a potential factor that may increase vulnerability to BV.
Methods: This systematic review analyzed studies published up to September 2023 using both national and international databases. Relevant keywords, including bacterial vaginosis, vitamin D, and 25-hydroxyvitamin D, were used in English and Persian searches. The methodological quality of the included studies was evaluated using the Newcastle–Ottawa Scale and the Jadad checklist.
Results:
A total of seven studies met the inclusion criteria. The overall methodological quality ranged from moderate to high. Approximately half of the studies reported a significant association between lower serum vitamin D levels and BV, while the remaining studies did not observe a statistically meaningful relationship.
Conclusion: Current evidence indicates a possible link between vitamin D status and bacterial vaginosis; however, the findings are not consistent across studies. Further well-designed prospective studies and randomized controlled trials are needed to clarify the role of vitamin D in the prevention and management of BV. Future research should also explore the effects of vitamin D on the vaginal microbiome, particularly in asymptomatic women.
Methods: This systematic review analyzed studies published up to September 2023 using both national and international databases. Relevant keywords, including bacterial vaginosis, vitamin D, and 25-hydroxyvitamin D, were used in English and Persian searches. The methodological quality of the included studies was evaluated using the Newcastle–Ottawa Scale and the Jadad checklist.
Results:
A total of seven studies met the inclusion criteria. The overall methodological quality ranged from moderate to high. Approximately half of the studies reported a significant association between lower serum vitamin D levels and BV, while the remaining studies did not observe a statistically meaningful relationship.
Conclusion: Current evidence indicates a possible link between vitamin D status and bacterial vaginosis; however, the findings are not consistent across studies. Further well-designed prospective studies and randomized controlled trials are needed to clarify the role of vitamin D in the prevention and management of BV. Future research should also explore the effects of vitamin D on the vaginal microbiome, particularly in asymptomatic women.
Keywords: Vitamin D, Bacterial Vaginosis, Serum 25-Hydroxyvitamin D, Systematic Review, Non-Pregnant Women, Vaginal Microbiome
Type of Study: Original Research Article |
Subject:
Clinical Medicine
Received: 2025/10/13 | Accepted: 2026/06/23
Received: 2025/10/13 | Accepted: 2026/06/23
References
1. Peebles K, Velloza J, Balkus JE, McClelland RS, Barnabas RV. High global burden and costs of bacterial vaginosis: A systematic review and meta-analysis. Sex Transm Dis. 2019; 46(5): 304-11. [DOI:10.1097/OLQ.0000000000000972] [PMID]
2. Abou Chacra L, Fenollar F, Diop K. Bacterial vaginosis: What do we currently know? Front Cell Infect Microbiol. 2021; 11: 672429. [DOI:10.3389/fcimb.2021.672429] [PMID] [PMCID]
3. Allsworth JE, Peipert JF. Severity of bacterial vaginosis and the risk of sexually transmitted infection. Am J Obstet Gynecol. 2011; 205(2): 113.e1-6. [DOI:10.1016/j.ajog.2011.02.060] [PMID] [PMCID]
4. Işik G, Demirezen Ş, Dönmez HG, Beksaç MS. Bacterial vaginosis in association with spontaneous abortion and recurrent pregnancy losses. J Cytol. 2016; 33(3): 135-40. [DOI:10.4103/0970-9371.188050] [PMID] [PMCID]
5. Muzny CA, Sobel JD. The role of antimicrobial resistance in refractory and recurrent bacterial vaginosis and current recommendations for treatment. Antibiotics (Basel). 2022; 11(4). [DOI:10.3390/antibiotics11040500] [PMID] [PMCID]
6. Owens DK, Davidson KW, Krist AH, Barry MJ, Cabana M, Caughey AB, et al. Screening for bacterial vaginosis in pregnant persons to prevent preterm delivery: US Preventive Services Task Force Recommendation Statement. JAMA. 2020; 323(13): 1286-92. [DOI:10.1001/jama.2020.2684] [PMID]
7. Bautista CT, Wurapa E, Sateren WB, Morris S, Hollingsworth B, Sanchez JL. Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections. Milit Med Res. 2016; 3(1): 4. [DOI:10.1186/s40779-016-0074-5] [PMID] [PMCID]
8. Bradshaw CS, Tabrizi S, Fairley CK, Morton AN, Rudland E, Garland SM. The association of atopobium vaginae and gardnerella vaginalis with bacterial vaginosis and recurrence after oral metronidazole therapy. J Infect Dis. 2006; 194(6): 828-36. [DOI:10.1086/506621] [PMID]
9. Bretelle F, Rozenberg P, Pascal A, Favre R, Bohec C, Loundou A, et al. High atopobium vaginae and gardnerella vaginalis vaginal loads are associated with preterm birth. Clin Infect Dis. 2015; 60(6): 860-7. [DOI:10.1093/cid/ciu966] [PMID]
10. Bradshaw CS, Sobel JD. Current treatment of bacterial vaginosis-limitations and need for innovation. J Infect Dis. 2016; 214(suppl_1): S14-S20. [DOI:10.1093/infdis/jiw159] [PMID] [PMCID]
11. Marshall AO. Managing recurrent bacterial vaginosis: Insights for busy providers. Sex Med Rev. 2015; 3(2): 88-92. [DOI:10.1002/smrj.45] [PMID]
12. Coudray MS, Madhivanan P. Bacterial vaginosis-A brief synopsis of the literature. Eur J Obstet Gynecol Reprod Biol. 2020; 245: 143-48. [DOI:10.1016/j.ejogrb.2019.12.035] [PMID] [PMCID]
13. Payne SC, Cromer PR, Stanek MK, Palmer AA. Evidence of African-American women's frustrations with chronic recurrent bacterial vaginosis. J Am Acad Nurse Pract. 2010; 22(2): 101-8. [DOI:10.1111/j.1745-7599.2009.00474.x] [PMID]
14. Bradshaw CS, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM, et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis. 2006; 193(11): 1478-86. [DOI:10.1086/503780] [PMID]
15. Zughaier SM, Lubberts E, Bener A. Editorial: immune-modulatory effects of vitamin D. Front Immunol. 2020; 11: 596611. [DOI:10.3389/fimmu.2020.596611] [PMID] [PMCID]
16. Ma L, Zhang Z, Li L, Zhang L, Lin Z, Qin H. Vitamin D deficiency increases the risk of bacterial vaginosis during pregnancy: Evidence from a meta-analysis based on observational studies. Front Nutr. 2022; 9: 1016592. [DOI:10.3389/fnut.2022.1016592] [PMID] [PMCID]
17. Nikvarz N, Berenji MG, Mousavy S, Vazifekhah N. Study of the effect of high dose vitamin D on the improvement of bacterial vaginosis in vitamin D deficient women. J Iran Med Council. 2023. [DOI:10.18502/jimc.v6i2.12236]
18. Taheri M, Baheiraei A, Foroushani AR, Nikmanesh B, Modarres M. Treatment of vitamin D deficiency is an effective method in the elimination of asymptomatic bacterial vaginosis: A placebo-controlled randomized clinical trial. Indian J Med Res. 2015; 141(6): 799. [DOI:10.4103/0971-5916.160707] [PMID] [PMCID]
19. Moore KR, Harmon QE, Baird DD. Serum 25-hydroxyvitamin D and risk of self-reported bacterial vaginosis in a prospective cohort study of young African American Women. J Women's Health. 2018; 27(10): 1278-1284. [DOI:10.1089/jwh.2017.6804] [PMID] [PMCID]
20. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, et al. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet Gynecol. 2014; 211(5): 479.e1-479.e13. [DOI:10.1016/j.ajog.2014.06.023] [PMID] [PMCID]
21. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 29; 372: n71. [DOI:10.1136/bmj.n71] [PMID]
22. Wells G, Shea B, O'connell D, Peterson J, Welch V, Losos M, et al. Newcastle-Ottawa quality assessment scale cohort studies. 2014; B-10]. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
23. Moher D, Jadad AR, Tugwell P. Assessing the quality of randomized controlled trials: current issues and future directions. Int J Technol Assess Health Care. 1996; 12(2): 195-208. [DOI:10.1017/S0266462300009570] [PMID]
24. Turner AN, Reese PC, Chen PL, Kwok C, Jackson RD, Klebanoff MA, et al. Serum vitamin D status and bacterial vaginosis prevalence and incidence in Zimbabwean women. Am J Obstet Gynecol. 2016; 215(3): 332. e1-332. e10. [DOI:10.1016/j.ajog.2016.02.045] [PMID] [PMCID]
25. Mojtahedi SF, Mohammadzadeh A, Mohammadzadeh F, Jalili Shahri J, Bahri N. Association between bacterial vaginosis and 25-Hydroxy vitamin D: a case-control study. BMC Infect Dis. 2023; 23(1): 1-10. [DOI:10.1186/s12879-023-08120-3] [PMID] [PMCID]
26. Rakhmatullaeva MM, Sharipova SU. Vitamin D deficiency in women with vaginal discharge. World Bullet Pub Health. 2022; 12: 70-72.
27. Dunlop AL, Taylor RN, Tangpricha V, Fortunato S, Menon R. Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy. Infect Dis Obstet Gynecol. 2011; 2011: 216217. [DOI:10.1155/2011/216217] [PMID] [PMCID]
28. Bitew A, Mengist A, Belew H, Aschale Y, Reta A. The prevalence, antibiotic resistance pattern, and associated factors of bacterial vaginosis among women of the reproductive age group from Felege Hiwot Referral Hospital, Ethiopia. Infect Drug Resist. 2021; 14(null): 2685-96. [DOI:10.2147/IDR.S305329] [PMID] [PMCID]
29. Leyva-Gómez G, Prado-Audelo MLD, Ortega-Peña S, Mendoza-Muñoz N, Urbán-Morlán Z, González-Torres M, et al. Modifications in vaginal microbiota and their influence on drug release: challenges and opportunities. Pharmaceutics. 2019; 11(5). [DOI:10.3390/pharmaceutics11050217] [PMID] [PMCID]
30. Grzesiak M, Tchurzyk M, Socha M, Sechman A, Hrabia A. An overview of the current known and unknown roles of vitamin D3 in the female reproductive system: lessons from farm animals, birds, and fish. Int J Mol Sci. 2022; 23(22): 14137. [DOI:10.3390/ijms232214137] [PMID] [PMCID]
31. Ismailova A, White JH. Vitamin D, infections and immunity. Rev Endoc Metab Disorder. 2022; 23(2): 265-77. [DOI:10.1007/s11154-021-09679-5] [PMID] [PMCID]
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