شنبه 2 اسفند 1404
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دوره 33، شماره 162 - ( Special Issue 1404 )
جلد 33 شماره 162 صفحات 87-81 |
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Ahmed S F, Aldabagh M A H, Khorshid A F, Hawezy D J. The Association of Interferon Lambda 4 (IFNL4) rs12979860 Polymorphism with COVID-19 Outcome. J Adv Med Biomed Res 2025; 33 (162) :81-87
URL: http://journal.zums.ac.ir/article-1-7889-fa.html
URL: http://journal.zums.ac.ir/article-1-7889-fa.html
The Association of Interferon Lambda 4 (IFNL4) rs12979860 Polymorphism with COVID-19 Outcome. Journal of Advances in Medical and Biomedical Research. 1404; 33 (162) :81-87
چکیده: (109 مشاهده)
Background & Objective: Coronavirus Disease 2019 (COVID-19) has a different fatality rate and clinical effects and exhibits a wide range of clinical symptoms, from asymptomatic to critically ill infections that require intensive care units. IFNL4 has shown antiviral activity against RNA viruses. IFNL4 is classified as a type-III interferon the newest addition to the interferon lambda protein family. The receptor of INFL4 (IFNLR1) is primarily restricted to tissues of epithelial origin. Therefore, interferon lambda proteins may have evolved specifically to protect the epithelium. Genetic polymorphism is one of the factors impacting COVID-19 outcomes. Variants of the IFNL4 gene have been linked to the clinical response to some viral infections. Many studies have found a correlation between the T Allele of IFNL4 (rs12979860) SNP and COVID-19 outcomes. Our goal was to investigate the correlation between such a polymorphism and the severity of COVID-19 infection.
Materials & Methods: A total of 150 positive COVID-19 patients (75 severe, 75 mild/moderate) were enrolled in the present study. The polymorphism was genotyped using TaqMan real-time PCR (polymerase chain reaction).
Results: The present study found the TT genotype of the rs12979860 variants was significantly prevalent in severe patients compared to mild and moderate infection patients, suggesting that this genotype could be a risk factor for COVID-19.
Conclusion: Between the two study groups, there is a statistically significant association between COVID-19 outcome and the T Allele of the IFNL4 (rs12979860) SNP.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Health Improvement Strategies
دریافت: 1404/7/19 | پذیرش: 1404/9/4 | انتشار: 1404/10/8
دریافت: 1404/7/19 | پذیرش: 1404/9/4 | انتشار: 1404/10/8
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