Volume 24, Issue 103 (4-2016)                   J Adv Med Biomed Res 2016, 24(103): 1-9 | Back to browse issues page

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Rezaei R, Almasi-Hashiani A, Rashidi A, Vaez S M, Khosravi A. The Effect of Intravitreal and Sub-Tenon Capsule Injection of Triamcinolone on the Visual Acuity in Diabetic Retinopathy Patients. J Adv Med Biomed Res 2016; 24 (103) :1-9
URL: http://journal.zums.ac.ir/article-1-3474-en.html
1- Dept. of Ophtalmology, Arak University of Medical Sciences, Arak, Iran , dr.rezarezaei@arakmu.ac.ir
2- Dept. of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
3- Dept. of Ophtalmology, Arak University of Medical Sciences, Arak, Iran
4- Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
5- Center for Health-Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran
Abstract:   (157402 Views)

Background and Objective: Macular edema is an important cause of visual loss in diabetic patients which can lead to permanent vision loss in untreated cases. This study compares the efficacy of intravitreal injection and the sub-tenon capsule of triamcinolone on the visual acuity in patients with diabetic retinopathy.

Materials and methods: In this randomized clinical trial study, 82 diabetic retinopathy eyes were randomly assigned to intravitreal triamcinolone injection group and 74 eyes to sub tenon capsule injection. In terms of visual acuity and intraocular pressure, patients were followed up after first week, first month, and 3rd month. The collected data were analyzed using ANOVA with repeated data (Repeated ANOVA) and  Stata software (version 13).

Results: Crude comparison between groups  did not exhibit significant differences. However, by controlling the confounding baseline effect, level of visual acuity, logMar[d1]  of the visual acuity in the  intravitreal injection group (-0.78) was significantly less than the sub-tenon capsule group (-0.67). Also, after controlling for other confounding variables (age and sex), the mean IOP was significantly higher in the intravitreal injection group.

Conclusion: [d2] Visual acuity in intravitreal injection group was significantly less than the sub-tenon capsule group and also the mean IOP was higher in the intravitreal injection group. Therefore, sub-tenon capsule of triamcinolone stands out as a superior approach.

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Type of Study: Clinical Trials |
Received: 2016/01/10 | Accepted: 2016/01/10 | Published: 2016/01/10

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