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Volume 25, Issue 113 (8-2017)
J Adv Med Biomed Res 2017, 25(113): 91-102 |
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Mahmoudi Mourderaz Y, Chaman R, Malekhosseini S A A, Sharifi A, Khosravani S A, Taher Rezanejad M, et al . Antimicrobial Resistance Pattern and agr Typing among Staphylococcus aureus Isolated from Nasal Carrier Personnel in Shahid Beheshti Hospital in Yasuj City. J Adv Med Biomed Res 2017; 25 (113) :91-102
URL: http://journal.zums.ac.ir/article-1-4800-en.html
URL: http://journal.zums.ac.ir/article-1-4800-en.html
Yaser Mahmoudi Mourderaz *1 
, Reza Chaman2 , Seyed Ali Asghar Malekhosseini1 , Asghar Sharifi3 , Seyed Abdolhamid Khosravani3 , Mohammad Taher Rezanejad1 , Maryam Hassani1 , Reza Mohammadi4 , Seyed Sajad Khoramrooz3
, Reza Chaman2 , Seyed Ali Asghar Malekhosseini1 , Asghar Sharifi3 , Seyed Abdolhamid Khosravani3 , Mohammad Taher Rezanejad1 , Maryam Hassani1 , Reza Mohammadi4 , Seyed Sajad Khoramrooz3
1- Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran
2- Dept. of Community Medicine, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
3- Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
4- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
2- Dept. of Community Medicine, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
3- Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
4- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract: (152739 Views)
Background and Objective: Based on the important role of nasal carriers of Staphylococcus aureus in hospital settings and their importance in the transmission of bacterium to patients and other personnel, the aim of the present study was to determine the frequency of nasal carriers, antibiotic resistance patterns and genotyping of S. aureus isolated from personnel of Shahid Beheshti hospital in Yasuj city (Iran) using the agr typing method.
Materials and Methods: In this cross-sectional study, a total of 347 nasal samples were collected from the healthcare workers of Shahid Beheshti Hospital in order to identify S. aureus. Cefoxitin containing disks and detection of the mecA gene were used for the identification of methicillin resistant isolates. The antimicrobial susceptibility patterns of isolates were tested against 15 different antibiotics using the Disc Agar Diffusion method. The Multiplex-PCR method was used for the agr typing of S. aureus isolates.
Results: Ninety-three (26.8%) of personnel were nasal carriers of S. aureus, among them 9 isolates were identified as MRSA. Among agr groups, agrI (40.9%) and agrIII (40.9%) were the prominent genotypes. All of the isolates (100%) were resistant to Penicillin. The resistance rate to erythromycin and co-trimoxazole were 12.9% and 5.38% respectively. Most of the isolates were sensitive to other antibiotics.
Conclusion: Based on the low resistance rate of S. aureus, it appears that the eradication of nasal carrier states could be possible. S. aureus agr types I and III have an important role in nasal colonization in comparison to other agr types.
Materials and Methods: In this cross-sectional study, a total of 347 nasal samples were collected from the healthcare workers of Shahid Beheshti Hospital in order to identify S. aureus. Cefoxitin containing disks and detection of the mecA gene were used for the identification of methicillin resistant isolates. The antimicrobial susceptibility patterns of isolates were tested against 15 different antibiotics using the Disc Agar Diffusion method. The Multiplex-PCR method was used for the agr typing of S. aureus isolates.
Results: Ninety-three (26.8%) of personnel were nasal carriers of S. aureus, among them 9 isolates were identified as MRSA. Among agr groups, agrI (40.9%) and agrIII (40.9%) were the prominent genotypes. All of the isolates (100%) were resistant to Penicillin. The resistance rate to erythromycin and co-trimoxazole were 12.9% and 5.38% respectively. Most of the isolates were sensitive to other antibiotics.
Conclusion: Based on the low resistance rate of S. aureus, it appears that the eradication of nasal carrier states could be possible. S. aureus agr types I and III have an important role in nasal colonization in comparison to other agr types.
Type of Study: Clinical Trials |
Received: 2017/08/27 | Accepted: 2017/08/27 | Published: 2017/08/27
Received: 2017/08/27 | Accepted: 2017/08/27 | Published: 2017/08/27
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