Volume 31, Issue 149 (November & December 2023)                   J Adv Med Biomed Res 2023, 31(149): 549-556 | Back to browse issues page

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Sadeghi A, Rostami M, Nasiri N, Hatami R, Karimi Moghaddam A, Karimi Moghaddam Z et al . Adverse Pregnancy Outcomes and Rheumatoid Arthritis: a Retrospective Matched Cohort Study. J Adv Med Biomed Res 2023; 31 (149) :549-556
URL: http://journal.zums.ac.ir/article-1-7131-en.html
Adverse Pregnancy Outcomes and Rheumatoid Arthritis: a Retrospective Matched Cohort Study
Alireza Sadeghi1 , Mina Rostami2 , Nazila Nasiri1 , Robabeh Hatami3 , Arezoo Karimi Moghaddam4 , Zhaleh Karimi Moghaddam5 , Alireza Zeraatchi *6
1- Dept. of Internal Medicine, School of Medicine, Vali-e-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
2- Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
3- Dept. of Obstetrics and Gynecology, School of Medicine, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
4- Dept. of Ophthalmology, School of Medicine, Vali-E-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
5- Dept. of Radiation Oncology, School of Medicine, Vali-e-asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
6- Dept. of Emergency Medicine, School of Medicine, Valiasr-e-Asr Hospital, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran , zeraatchi.zums@gmail.com
Abstract:   (2443 Views)

Background and Objective: Rheumatoid Arthritis (RA) is an autoimmune-driven chronic systemic inflammatory disease. It could result in miscarriage, pre-eclampsia, and preterm labor, among other unfavorable pregnancy outcomes. Thus, this study was conducted to investigate the adverse pregnancy outcomes in pregnant women with RA.
Materials and Methods: Two cohorts of pregnant women with and without RA referred to the Ayatollah Mousavi Hospital's Gynecology and Obstetrics Clinic in Zanjan, Iran, during 2019-2020 were enrolled in a retrospective matched cohort study. Using their medical records, each participant completed a checklist of study variables. We used binary Logistic regression, chi-square test, Analysis of Variance, and independent samples t-test to analyze data using SPSS v.23.
Results: The study included 280 pregnant women. The mean age of the RA and control group (pregnant women without RA) was 32.4 ± 6.6 and 29.5 ± 6.7 years, respectively. The most prevalent adverse outcome was spontaneous abortion (54, 19.28%), which was significantly higher in the RA group (25% vs. 13.6%, P= 0.015). Cesarean section (24.3% vs. 10.7%, P= 0.003) and low birth weight (LBW) were both significantly higher in the RA group (15% vs. 5%, P= 0.005). RA increased the probability of spontaneous abortion, cesarean section, and LBW by more than 1.3 (odds ratio, 1.38; 95% CI, 0.45-5.46; P= 0.017), 2.2 (odds ratio, 2.24; 95% CI, 1.29-6.54; P =0.004), and 2.6 (odds ratio, 2.67; 95% CI, 1.86-7.05; P= 0.008) times, respectively.
Conclusion: Pregnant women with RA are more likely to experience spontaneous abortion, cesarean section, and having LBW infants comparing to pregnant women without RA.

Keywords: Rheumatoid Arthritis, Pregnancy, Cesarean Section, Spontaneous Abortion, Low Birth Weight
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✅ Pregnant women with RA are more likely to experience spontaneous abortion, cesarean section, and having LBW infants comparing to pregnant women without RA.


Type of Study: Original Research Article | Subject: Clinical Medicine
Received: 2023/08/23 | Accepted: 2023/11/6 | Published: 2024/01/29
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