Background and Aims: This study aimed to investigate the relationship between vitamin D deficiency and hormonal (follicle-stimulating hormone [FSH], estradiol, thyroid-stimulating hormone [TSH], triiodothyronine [T3], thyroxine [T4]) and biochemical parameters (insulin resistance, calcium, and C-reactive protein [CRP]) in women with hyperprolactinemia.
Materials and Methods: The study included 40 women aged 30–40 years, divided into two groups: 20 women with hyperprolactinemia and 20 healthy controls. Hormonal and biochemical parameters were measured in both groups, and comparisons were made to assess the effect of vitamin D deficiency.
Results: FSH levels increased in the hyperprolactinemia group but were not statistically significant, while estradiol showed a significant increase (P ≤ 0.01). TSH and T4 levels were also significantly elevated (P ≤ 0.01), whereas T3 increased significantly (P ≤ 0.05) compared with the control group. Insulin resistance (P≤0.05) and CRP (P≤0.01) were significantly higher in the hyperprolactinemic group. Serum calcium levels decreased significantly (P ≤ 0.05) compared with the control group.
Conclusion: Vitamin D deficiency in hyperprolactinemic women may be associated with various hormonal and metabolic disturbances. These include alteration of reproductive and thyroid hormone levels and elevation of inflammatory markers, suggesting that vitamin D deficiency may contribute to broader endocrine and biochemical dysregulation.