Volume 33, Issue 159 (July & August 2025)                   J Adv Med Biomed Res 2025, 33(159): 328-333 | Back to browse issues page

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Alwan F K, Khalifa A A. Insulin Resistance, Ca, C-reactive Protein and Some Hormonal Parameters Related with Vitamin D Deficiency in Hyperprolactinemic Women. J Adv Med Biomed Res 2025; 33 (159) :328-333
URL: http://journal.zums.ac.ir/article-1-7782-en.html
Insulin Resistance, Ca, C-reactive Protein and Some Hormonal Parameters Related with Vitamin D Deficiency in Hyperprolactinemic Women
Farah Kadhim Alwan *1 , Ahmed Aboud Khalifa2
1- Department of Biology, College of Science, University of Misan, Maysan, Iraq , farahka9624@gmail.com
2- Department of Biology, College of Science, University of Misan, Maysan, Iraq
Abstract:   (148 Views)

Background & Objective: This study aimed to investigate the relationship between vitamin D deficiency and hormonal (follicle-stimulating hormone [FSH], estradiol, thyroid-stimulating hormone [TSH], triiodothyronine [T3], thyroxine [T4]) and biochemical parameters (insulin resistance, calcium, and C-reactive protein [CRP]) in women with hyperprolactinemia.
Materials & Methods: The study included 40 women aged 30–40 years, divided into two groups: 20 women with hyperprolactinemia and 20 healthy controls. Hormonal and biochemical parameters were measured in both groups, and comparisons were made to assess the effect of vitamin D deficiency.
Results: FSH levels increased in the hyperprolactinemia group but were not statistically significant, while estradiol showed a significant increase (P ≤ 0.01). TSH and T4 levels were also significantly elevated (P ≤ 0.01), whereas T3 increased significantly (P ≤ 0.05) compared with the control group. Insulin resistance (P≤0.05) and CRP (P≤0.01) were significantly higher in the hyperprolactinemic group. Serum calcium levels decreased significantly (P ≤ 0.05) compared with the control group.
Conclusion: Vitamin D deficiency in hyperprolactinemic women may be associated with various hormonal and metabolic disturbances. These include alteration of reproductive and thyroid hormone levels and elevation of inflammatory markers, suggesting that vitamin D deficiency may contribute to broader endocrine and biochemical dysregulation.

Keywords: Vitamin D Deficiency, Hyperprolactinemia, Insulin Resistance, CRP, Calcium
     
Type of Study: Original Research Article | Subject: Medical Biology
Received: 2025/07/7 | Accepted: 2025/09/15 | Published: 2025/09/29
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