Volume 31, Issue 149 (November & December 2023)
Potential Role of Oxidative Stress on the Pathophysiology of Neuropathic Pain in the Inflammatory Diseases
✅ In this review, data on oxidative stress and inflammation is compiled and discussed in the context of chronic neuropathic pain.It is suggested that oxidative stress can activate a variety of pro-inflammatory factors involved in chronic diseases.
Identification Biomarkers and Molecular Mechanisms Involved in Lung Transplant Rejection, and Drug Repurposing: A Systems Biology Study
✅ Following our model validation using the existing experimental data, our model suggested critical molecules and candidate medicines involve in surfactant function in rejection of lung transplantation for furtur investigations.
Assessment of Aesthetic Outcomes of Spreader Graft for Primary Rhinoplasty in Patients with Mild Dorsal Hump Reduction, A Double Blind Clinical Trial
✅ Using a spreader graft in the primary rhinoplasty of patients with less than 3mm hump reduction, without causing serious complications, increases the patient’s satisfaction with dorsum aesthetics.
Effects of High Power Laser Therapy on Clinical and Sonographic Findings in People with Chronic Rotator Cuff Tendinitis
, Abbas Soltani , Bina Eftekharsadat , Parvin Sarbakhsh , Mehrdad Habibi , Ali E. Oskouei *
✅ HPLT combined with the routine physiotherapy improve the clinical as well as sonography findings including supraspinatus tendon thickness and accumulation of sub-acromial fluid in people with rotator cuff tendinitis compared with those in the control group.
, Mina Rostami , Nazila Nasiri , Robabeh Hatami , Arezoo Karimi Moghaddam , Zhaleh Karimi Moghaddam , Alireza Zeraatchi *
✅ Pregnant women with RA are more likely to experience spontaneous abortion, cesarean section, and having LBW infants comparing to pregnant women without RA.
A Comparison of Willingness to Pay for Substance Use Disorder Treatment in Methadone Maintenance Clinics and Residential Facilities: The Role of Cost Payers' Income and Patients' Addiction Severity
✅ When clients and their families bear the full cost of treatment, cost payers' income plays a key role in preparedness for purchasing treatment services. The severity of substance use disorder is the second factor determining WTP for treatment.
The Correlation between HSP27 Protein Levels and Gene Expression with Symptoms Severity in COVID-19 Patients
✅ The present study, to date, is the first to investigate HSP27 gene expression levels in COVID-19 patients. Conducting further studies on HSP27 is of considerable help to clarify the importance of this molecule in SARS-CoV-2 infection.
Microvesicles Derived from Human Placental Mesenchymal Stem Cells Induce Autophagy and Apoptosis in Acute Myeloid Leukemia
✅ Our findings indicate that hPMSC-MVs induce Cell death pathways of autophagy and apoptosis in the KG1 cell lines. Additionally, hPMSC-MVs exhibited heightened impactful anti-proliferative and pro-apoptotic outcomes on KG1 cells in vitro.
✅ Due to the presence of β-carbolines, the P. harmala seed extract has toxicity and affects insulin secretion and C-peptide uptake secretion at lower concentrations than those of leaf extract.
Targeting Positive Regulators of Sonic Hedgehog Signaling Pathway in Medulloblastoma by Designing CRISPR/Cas9 Single Guide RNAs
✅ This study revealed possible specific exonic targets of components of the SHH signaling pathway through designing proper sgRNAs using the CRISPR/Cas9 genome editing approach.
Serum Levels of Tripartite Motif-containing Protein 72 (TRIM72) in Iraqi Rheumatoid Arthritis Patients and Its Relevance to the Disease Activity State
✅ There was a positive relationship between DAS-28ESR and Tripartite motif-containing protein 72 levels, which induces bone erosion. The serum Tripartite motif-containing protein 72 level showed a significant elevation in rheumatoid arthritis patients compared with healthy controls. Tripartite motif-containing protein 72 had a poor discriminative ability between RA and the control group.
A Novel Heterozygous Pathogenic Mutation of PPP2RIA Gene in a Pediatric Encephalopathy Patient: A Case Report
✅ This study reports clinical laboratory, radiological, and magnetic resonance imaging (MRI) findings as well as whole-exome sequencing (WES) of a female patient aged 19 months and 7 days with encephalopathy. The limitation of this study such as lack of access to the patients or biological samples of other similar patients hindered further evaluation. Hence, comprehensive research must be conducted to reveal the underlying etiology.
