Volume 31, Issue 146 (May & June 2023)                   J Adv Med Biomed Res 2023, 31(146): 261-267 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Daya A, Namiranian N, Razavi Ratki S K, Amlelshahbaz A P, Razavi R, Nafisi Moghadam R. Comparison of RT-PCR and CT Scan in Terms of Their Diagnostic Performance for Coronavirus 2019 in Yazd, Iran. J Adv Med Biomed Res 2023; 31 (146) :261-267
URL: http://journal.zums.ac.ir/article-1-6815-en.html
1- Dept. of Radiology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Dept. of Radiology, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Dept. of Radiology, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , nafisi.moghadam@gmail.com
Abstract:   (2791 Views)

Background and Objective: Due to the importance of the rapid diagnosis of SARS-COV-2, many studies have been performed on various diagnostic methods. In this vein, the aim of this study is to compare the diagnostic value of chest CT with RT-PCR in patients with suspected COVID-19.
Materials and Methods: This cross-sectional research was conducted at Shahid Sadoughi Hospital in Yazd. A total of 531 patients were randomly referred to the CT scan department for chest imaging (spiral or HRCT).Based on the PCR findings, they were divided into: positive and negative PCR groups. The CT scan findings were then recorded in a data collection form. Finally, the CT scan results of the two groups were compared.
Results: In this study, 531 patients (306 males and 225 females with the mean age of 55.14 ± 19.7) were examined. The findings of reverse hallo (P = 0.000) and strict consolidation (P= 0.001) in CT scan were significantly different for the positive and negative PCR groups. Through the comparative analysis of the results, the sensitivity of CT scan and PCR findings emerged to be 97.42 and 55.75, respectively. However, the specificity of both diagnostic methods was 100%.
Conclusion: The results of this study show that, owing to the higher sensitivity of chest CT for the diagnosis of COVID-19 pneumonia, performing CT scan for quick diagnosis is recommended for COVID suspected people with negative RT-PCR test results.

Full-Text [PDF 370 kb]   (1602 Downloads) |   |   Full-Text (HTML)  (409 Views)  

 The results of this study show that, owing to the higher sensitivity of chest CT for the diagnosis of COVID-19 pneumonia, performing CT scan for quick diagnosis is recommended for COVID suspected people with negative RT-PCR test results.


Type of Study: Original Article | Subject: Clinical medicine
Received: 2022/08/8 | Accepted: 2023/01/20 | Published: 2023/06/26

References
1. Phelan AL, Katz R, Gostin LO. The novel coronavirus originating in Wuhan, China: challenges for global health governance. Jama. 2020;323(8):709-10. [DOI:10.1001/jama.2020.1097] [PMID]
2. Wu Y, Ho W, Huang Y, et al. SARS-CoV-2 is an appropriate name for the new coronavirus. The Lancet. 2020;395(10228):949-50. [DOI:10.1016/S0140-6736(20)30557-2] [PMID]
3. Long C, Xu H, Shen Q, et al. Diagnosis of the coronavirus disease (COVID-19): rRT-PCR or CT? Europ J Radiol. 2020;126:108961. [DOI:10.1016/j.ejrad.2020.108961] [PMID] [PMCID]
4. Legido-Quigley H, Asgari N, Teo YY, et al. Are high-performing health systems resilient against the COVID-19 epidemic? The Lancet. 2020;395(10227):848-50. [DOI:10.1016/S0140-6736(20)30551-1] [PMID]
5. Wang P, Anderson N, Pan Y, et al. The SARS-CoV-2 outbreak: diagnosis, infection prevention, and public perception. Clin Chem. 2020;66(5):644-51. [DOI:10.1093/clinchem/hvaa080] [PMID] [PMCID]
6. Khot WY, Nadkar MY. The 2019 novel coronavirus outbreak-a global threat. J Assoc Physicians India. 2020;68(3):67-71.
7. Ye Q, Wang B, Mao J. The pathogenesis and treatment of the Cytokine Storm'in COVID-19. J Infect. 2020;80(6):607-13. [DOI:10.1016/j.jinf.2020.03.037] [PMID] [PMCID]
8. Poortahmasebi V, Zandi M, Soltani S, Jazayeri SM. Clinical performance of RT-PCR and chest CT scan for COVID-19 diagnosis; a systematic review. Front Emerg Med. 2020;4(2s):e57-e.
9. Ai T, Yang Z, Hou H, et al. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology. 2020; 296(2):E32-E40 [DOI:10.1148/radiol.2020200642] [PMID] [PMCID]
10. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. Jama. 2020;323(11):1061-9. [DOI:10.1001/jama.2020.1585] [PMID] [PMCID]
11. He JL, Luo L, Luo ZD, et al. Diagnostic performance between CT and initial real-time RT-PCR for clinically suspected 2019 coronavirus disease (COVID-19) patients outside Wuhan, China. Respir Med. 2020;168:105980. [DOI:10.1016/j.rmed.2020.105980] [PMID] [PMCID]
12. Ng MY, Lee EY, Yang J, et al. Imaging profile of the COVID-19 infection: radiologic findings and literature review. Radiol Cardiothorac Imaging. 2020;2(1): e200034 [DOI:10.1148/ryct.2020200034] [PMID] [PMCID]
13. Bernheim A, Mei X, Huang M, et al. Chest CT findings in coronavirus disease-19 (COVID-19): relationship to duration of infection. Radiology. 2020. [DOI:10.1148/radiol.2020200463] [PMID] [PMCID]
14. Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J. Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing. Radiology. 2020.
15. Yang W, Yan F. Patients with RT-PCR-confirmed COVID-19 and normal chest CT. Radiology. 2020;295(2):E3-E. [DOI:10.1148/radiol.2020200702] [PMID] [PMCID]
16. Zhang Z, Yao W, Wang Y, Long C, Fu X. Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources. J Infect. 2020;81(1):147-78. [DOI:10.1016/j.jinf.2020.03.018]
17. Chan JF-W, Yip CC-Y, To KK-W, et al. Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-PCR assay validated in vitro and with clinical specimens. J Clin Microbiol. 2020;58(5):e00310-20. [DOI:10.1128/JCM.00310-20] [PMID] [PMCID]
18. Hao W, Li M. Clinical diagnostic value of CT imaging in COVID-19 with multiple negative RT-PCR testing. Travel Med Infect Dis. 2020;34:101627. [DOI:10.1016/j.tmaid.2020.101627] [PMID] [PMCID]
19. Dangis A, Gieraerts C, De Bruecker Y, et al. Accuracy and reproducibility of low-dose submillisievert chest CT for the diagnosis of COVID-19. Radiol Cardiothorac Imaging. 2020;2(2): e200196. [DOI:10.1148/ryct.2020200196] [PMID] [PMCID]
20. Fang Y, Zhang H, Xie J, et al. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology. 2020. [DOI:10.1148/radiol.2020200432] [PMID] [PMCID]
21. Bai HX, Hsieh B, Xiong Z, et al. Performance of radiologists in differentiating COVID-19 from non-COVID-19 viral pneumonia at chest CT. Radiology. 2020;296(2):E46-E54. [DOI:10.1148/radiol.2020200823] [PMID] [PMCID]
22. Schultz CH, Fairley R, Murphy LS L, Doss M. The risk of cancer from CT scans and other sources of low-dose radiation: a critical appraisal of methodologic quality. Prehosp Disaster Med. 2020;35(1):3-16. [DOI:10.1017/S1049023X1900520X] [PMID]

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb