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Volume 32, Issue 155 (November & December 2024)
J Adv Med Biomed Res 2024, 32(155): 405-414 |
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Khoshhal A R, Esmaili Torshabi A, Babamohammadi S. Investigation of the Produced Positrons and Their Dose Deposition at Bone and Soft Tissue Organs at Proton Therapy: A Simulation Study. J Adv Med Biomed Res 2024; 32 (155) :405-414
URL: http://journal.zums.ac.ir/article-1-7586-en.html
URL: http://journal.zums.ac.ir/article-1-7586-en.html
1- Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran , amirrezakhoshhal79@gmail.com
2- Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran
2- Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran
Abstract: (250 Views)
Background & Objective: Proton therapy has emerged as a superior method in cancer treatment compared to traditional photon-based radiation therapies. Because of the unique physical features of protons and Bragg curve, it can deliver the greatest dosage directly to the tumor while minimizing the radiation absorbed by surrounding healthy tissues. By spreading out Bragg Peak, proton therapy ensures that the tumor receives the prescribed high dose while reducing side effects. In proton therapy, the positrons play a significant role in dose monitoring and imaging.
Materials & Methods: In this research, GEometry ANd Tracking (GEANT4) simulation code was used to study the number of positrons emitted and their dose depositions during proton therapy at energies of 50 and 100 MeV in both soft tissue and bone with variety of densities.
Results: The results showed that for 50 MeV protons, 15O was identified as the positron emitter that emits the most positrons in both tissues at two energies. The maximum penetration depth of 50 MeV proton beam was 26 mm in soft tissue and 16 mm in bone, while at 100 MeV, the depth was 89 mm in soft tissue and 53 mm in bone. Furthermore, the dose deposition by positrons decreases by increasing tissue density.
Conclusion: In proton therapy 50 and 100 MeV the most positrons emitted from 15O, 11C, 30P, 13N, 38k, 39Ca in soft tissue and bone.
Materials & Methods: In this research, GEometry ANd Tracking (GEANT4) simulation code was used to study the number of positrons emitted and their dose depositions during proton therapy at energies of 50 and 100 MeV in both soft tissue and bone with variety of densities.
Results: The results showed that for 50 MeV protons, 15O was identified as the positron emitter that emits the most positrons in both tissues at two energies. The maximum penetration depth of 50 MeV proton beam was 26 mm in soft tissue and 16 mm in bone, while at 100 MeV, the depth was 89 mm in soft tissue and 53 mm in bone. Furthermore, the dose deposition by positrons decreases by increasing tissue density.
Conclusion: In proton therapy 50 and 100 MeV the most positrons emitted from 15O, 11C, 30P, 13N, 38k, 39Ca in soft tissue and bone.
Type of Study: Original Research Article |
Subject:
Clinical Medicine
Received: 2024/10/9 | Accepted: 2025/01/5 | Published: 2024/10/10
Received: 2024/10/9 | Accepted: 2025/01/5 | Published: 2024/10/10
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