Patient blood management (PBM) originated as a multidisciplinary, patient-centric strategy in the 1970s, designed to minimize the utilization of allogeneic blood transfusions. During pandemic events, including HIV, influenza, and COVID-19, PBM adoption was significantly amplified. The implementation of PBM demonstrably contributes to the enhancement of patient clinical outcomes, the reduction of healthcare expenditures, and the improvement of patient safety. A primary obstacle to PBM integration is resistance to paradigm shifts and the persistence of obsolete methodologies, necessitating comprehensive educational interventions and heightened awareness among healthcare professionals. Considering the escalating demand for blood components and the inherent complexities of blood resource management, the effective execution of PBM is crucial and of paramount importance for future healthcare sustainability.