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1- , amir_saheb2000@yahoo.com
Abstract: (6 Views)
Background:Bacterial vaginosis (BV) is one of the most frequent vaginal infections and has been linked to unfavorable reproductive outcomes. Vitamin D is known to play a key role in regulating immune function, and its deficiency has been proposed as a potential factor that may increase vulnerability to BV.
Methods: This systematic review analyzed studies published up to September 2023 using both national and international databases. Relevant keywords, including bacterial vaginosis, vitamin D, and 25-hydroxyvitamin D, were used in English and Persian searches. The methodological quality of the included studies was evaluated using the Newcastle–Ottawa Scale and the Jadad checklist.
Results:
A total of seven studies met the inclusion criteria. The overall methodological quality ranged from moderate to high. Approximately half of the studies reported a significant association between lower serum vitamin D levels and BV, while the remaining studies did not observe a statistically meaningful relationship.
Conclusion: Current evidence indicates a possible link between vitamin D status and bacterial vaginosis; however, the findings are not consistent across studies. Further well-designed prospective studies and randomized controlled trials are needed to clarify the role of vitamin D in the prevention and management of BV. Future research should also explore the effects of vitamin D on the vaginal microbiome, particularly in asymptomatic women.
Methods: This systematic review analyzed studies published up to September 2023 using both national and international databases. Relevant keywords, including bacterial vaginosis, vitamin D, and 25-hydroxyvitamin D, were used in English and Persian searches. The methodological quality of the included studies was evaluated using the Newcastle–Ottawa Scale and the Jadad checklist.
Results:
A total of seven studies met the inclusion criteria. The overall methodological quality ranged from moderate to high. Approximately half of the studies reported a significant association between lower serum vitamin D levels and BV, while the remaining studies did not observe a statistically meaningful relationship.
Conclusion: Current evidence indicates a possible link between vitamin D status and bacterial vaginosis; however, the findings are not consistent across studies. Further well-designed prospective studies and randomized controlled trials are needed to clarify the role of vitamin D in the prevention and management of BV. Future research should also explore the effects of vitamin D on the vaginal microbiome, particularly in asymptomatic women.
Keywords: Vitamin D, Bacterial Vaginosis, Serum 25-Hydroxyvitamin D, Systematic Review, Non-Pregnant Women, Vaginal Microbiome
Type of Study: Original Research Article |
Subject:
Clinical Medicine
Received: 2025/10/13 | Accepted: 2026/06/23
Received: 2025/10/13 | Accepted: 2026/06/23
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