Thu, Jun 5, 2025
[Archive]
Volume 10, Issue 38 (3-2002)
J Adv Med Biomed Res 2002, 10(38): 12-16 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Johari H, Oryan S, Parivar K, Haeri Rouhani A, Tanide N. Effect Of Adenine On Chemical Composition Of Serum And Urine Osmolality In Male Sprague- Dawly Rats. J Adv Med Biomed Res 2002; 10 (38) :12-16
URL: http://journal.zums.ac.ir/article-1-416-en.html
URL: http://journal.zums.ac.ir/article-1-416-en.html
Abstract: (148760 Views)
Background: Chronic renal failure leads to several functional disturbances in the regulation of body fluid composition, excretion, and metabolism which is known as uremic syndrome. There are reports of chronic renal disturbances following adenine containing food regimens in animals. In this study, the effect of intraperitoneal injection of soluble adenine on chemical composition of serum and urine osmolality was investigated.
Materials and Methods: In this experimental study different concentrations of soluble adenine were injected to Sprague-Dawly rats from days 2 to 16 after birth. Factors such as serum and urine osmolality, urine volume and serum chemical factors such as glucose, urea, creatinine, sodium, potassium and body weight were measured after the injection of adenine up to 140 days.
Results: Serum osmolality, urea and creatinine increased after adenine injections, while body weight, urine osmolality and urine volume decreased. Meanwhile, the concentration of serum glucose, sodium and potassium did not show any significant changes.
Conclusion: Adenine induces an imbalance in many chemical factors of serum in chronic renal failure. Further studies on the effect of adenine reduction in diet on uremic syndrome are recommended.
Materials and Methods: In this experimental study different concentrations of soluble adenine were injected to Sprague-Dawly rats from days 2 to 16 after birth. Factors such as serum and urine osmolality, urine volume and serum chemical factors such as glucose, urea, creatinine, sodium, potassium and body weight were measured after the injection of adenine up to 140 days.
Results: Serum osmolality, urea and creatinine increased after adenine injections, while body weight, urine osmolality and urine volume decreased. Meanwhile, the concentration of serum glucose, sodium and potassium did not show any significant changes.
Conclusion: Adenine induces an imbalance in many chemical factors of serum in chronic renal failure. Further studies on the effect of adenine reduction in diet on uremic syndrome are recommended.
Type of Study: Original Research Article |
Received: 2008/11/10 | Accepted: 2002/03/15 | Published: 2002/03/15
Received: 2008/11/10 | Accepted: 2002/03/15 | Published: 2002/03/15
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright Policy
