Background and Objective: Diabetes mellitus is one of the most important metabolic disorders worldwide. So far, numerous medicinal plants have been used to treat diabetes mellitus. Echium amoenum L. (EA) is one of the important medicinal herbs in Iranian traditional medicine. In the present study, the effects of EA hydroalcoholic extract on blood glucose, lipid profile and lipoproteins were studied in diabetic male rats. Materials and Methods: In this study, 30 male Wistar rats were randomly divided into five groups with six rats in each: normal control diabetic control and diabetic rats treated with hydroalcoholic extract of EA (100, 400 and 600 mg/kg). Diabetes was induced in the rats by administrating a single dose of streptozotocine (60 mg/kg, ip). Injection of extract was done intraperitoneally for 30 days. Finally, blood samples were taken and the concentration of glucose, triglyceride, cholesterol, HDL-C and LDL-C in the serum was measured. 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