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J Adv Med Biomed Res 2019, 27(120): 8-13 |
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Setorki M, Hooshmandi Z, Zanganehnejad Z. The effects of Biarum carduchrum hydroalcoholic extract on oxidative stress and catalepsy in the 6-hydroxydopamine-induced rat model of Parkinson's disease. J Adv Med Biomed Res 2019; 27 (120) :8-13
URL: http://journal.zums.ac.ir/article-1-5234-en.html
URL: http://journal.zums.ac.ir/article-1-5234-en.html
1- Dept. of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
2- Dept. of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
3- Dept. of Biology, Shahrekord Branch, Islamic Azad University, shahrekord, Iran ,zzanganehnejad@yahoo.com
2- Dept. of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
3- Dept. of Biology, Shahrekord Branch, Islamic Azad University, shahrekord, Iran ,
Abstract: (145533 Views)
Background and Objective: Parkinson is a neurodegenerative disease that leads to incurable and debilitating conditions. Herbal extracts can afford protection against neurodegenerative diseases due to their bioactive compounds. In the present study, we investigated the effect of hydro-alcoholic extract of B. carduchrum on catalepsy and brain oxidative stress in rat’s model of Parkinson’s disease.
Materials and Methods: Rats were randomly divided into five groups of eight animals. The control group was left intact. Parkinsonian group received an injection of 6-hydroxydopamine (6-OHDA) in the right anterior mid-brain. Extract treated groups received hydro-alcoholic extract of B. carduchrum at doses of 100, 200 and 400mg/kg by gavage seven days after 6-OHDA injection. 14 days after treatment, bar test was performed and lipid peroxide levels of different brain regions were determined. Data were analyzed by ANOVA followed by Tukey's test using SPSS software and P<0.05 was considered statistically significant.
Results: In 6-OHDA-lesioned group, bar time was increased significantly (P<0.05) when compared with the control group (122.50±90.12 versus 0.00±0.00). B. carduchrum at doses of 200 and 400mg/kg significantly reduced 6-OHDA induced catalepsy (P<0.0.5). 6-OHDA treatment leads to significant increases in lipid peroxide levels of cerebellum, cortex, hippocampus and striatum (P<0.05). Administration of B. carduchrum extract at different doses caused significant reduction in the lipid peroxide levels of different brain regions (P<0.05).
Conclusion: B. carduchrum extract ameliorated 6-OHDA -induced catalepsy and lipid peroxide level of brain in rat’s model of Parkinson’s disease.
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✅ B. carduchrum extract ameliorated 6-OHDA -induced catalepsy and lipid peroxide level of brain in rat’s model of Parkinson’s disease.
Type of Study: Original Research Article |
Subject:
Medical Laboratory and Animal Investigation
Received: 2018/06/26 | Accepted: 2019/08/27 | Published: 2019/09/16
Received: 2018/06/26 | Accepted: 2019/08/27 | Published: 2019/09/16
References
1. Jackson-Lewis V, Blesa J, Przedborski S. Animal models of Parkinson's disease. Parkinsonism & related disorders. 2012; 18: S183-S5. [DOI:10.1016/S1353-8020(11)70057-8]
2. Bohnen NI, Albin RL. The cholinergic system and Parkinson disease. Behav Brain Res. 2011; 221(2): 564-73. [DOI:10.1016/j.bbr.2009.12.048] [PMID] [PMCID]
3. Ahlskog JE. editor Aerobic exercise: evidence for a direct brain effect to slow parkinson disease progression. Mayo Clinic Proceedings; 2018: Elsevier. [DOI:10.1016/j.mayocp.2017.12.015] [PMID]
4. Hirsch EC, Jenner P, Przedborski S. Pathogenesis of Parkinson's disease. Movement Disorder. 2013; 28(1): 24-30. [DOI:10.1002/mds.25032] [PMID]
5. Zhou C, Huang Y, Przedborski S. Oxidative stress in Parkinson's disease. Ann New York Acad Sci. 2008; 1147(1): 93-104. [DOI:10.1196/annals.1427.023] [PMID] [PMCID]
6. Hwang O. Role of oxidative stress in Parkinson's disease. Experiment Neurobiol. 2013; 22(1): 11-7. [DOI:10.5607/en.2013.22.1.11] [PMID] [PMCID]
7. Henchcliffe C, Beal MF. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nature Rev Neurol. 2008; 4(11): 600-9. [DOI:10.1038/ncpneuro0924] [PMID]
8. Jadiya P, Khan A, Sammi SR, Kaur S, Mir SS, Nazir A. Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease. Biochem Biophysic Res Commun. 2011; 413(4): 605-10. [DOI:10.1016/j.bbrc.2011.09.010] [PMID]
9. Farahmandfar R, Ramezanizadeh MH. Oxidative stability of canola oil by Biarum bovei bioactive components during storage at ambient temperature. Food Sci Nutr. 2018; 6: 342-47. [DOI:10.1002/fsn3.560] [PMID] [PMCID]
10. Zanganehnejad Z, Setorki M. Effect of Biarum carduchrum extract on brain tissue thiol level in rat model of 6-hydroxydopamine-induced Parkinson's disease. J Herb Med Pharmacol. 2018; 7(3): 136-40. [DOI:10.15171/jhp.2018.23]
11. Hosseini E, Rousta E, Tabib Loghmany F, Mahmoudpour M. In vitro antioxidant activity of hydromethanolic extract of Karde (Biarum carduchrum) and tts effects on the serum lipids of rats. Iran J Nut Sci Food Technol. 2014; 9(3): 1-8.
12. Pisoschi AM, Pop A. The role of antioxidants in the chemistry of oxidative stress: A review. Europ J Med Chem. 2015; 97: 55-74. doi: 10.1016/j.ejmech.2015.04.040. [DOI:10.1016/j.ejmech.2015.04.040] [PMID]
13. SeifiZangeneh M, Rafieirad M, Sazgar H. The effect of Kardeh (BiarumBovei) hydro-alcoholic extract on pain threshold in STZ induced diabetic rats. J Herb Drug. 2015; 6(3): 137-42.
14. Simola N, Morelli M, Carta A. The 6-hydroxydopamine model of Parkinson'sdisease. Neurotoxic Res. 2008; 11(1): 151-67. [DOI:10.1007/BF03033565] [PMID]
15. Rafieiradorcid M, Doulahorcid A, Rostami SA. Effects of strawberry (Fragaria ananassa) extract on 6-hydroxy dopamine induced parkinson's disease model in male rats. Report Health Care J. 2016; 2(3): 1-8.
16. Goudarzi S, Rafieirad M. Evaluating the effect of α-pinene on motor activity, avoidance memory and lipid peroxidation in animal model of Parkinson disease in adult male rats. Res J Pharmacog. 2017; 4(2): 53-63.
17. Olfert ED, Cross BM, McWilliam AA. Guide to the care and use of experimental animals: Canadian Council on Animal Care Ottawa; 1993.
18. Salar F, Ziai S, Nasri S, Roghani M, Kamalinejad M. Neuroprotective effect of aqueous extract of Berberis vulgaris L. in a model of parkinson's disease in rat. J Med Phys. 2010; 4(36): 24-33.
19. Mansouri SMT, Naghizadeh B, Hosseinzadeh H. The effect of Pistacia vera L. gum extract on oxidative damage during experimental cerebral ischemia-reperfusion in rats. Iran Biomed J. 2005; 9(4): 181-5.
20. Kheradmand A, Nayebi AM, Jorjani M, Haddadi R. Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. Iran J Basic Med Sci. 2016; 19(5): 490-6.
21. Haddadi R, Nayebi AM, Farajniya S, Brooshghalan SE, Sharifi H. Silymarin improved 6-OHDA-induced motor impairment in hemi-parkisonian rats: behavioral and molecular study. DARU. 2014; 22(1): 38. [DOI:10.1186/2008-2231-22-38] [PMID] [PMCID]
22. Khan MM, Ahmad A, Ishrat T, et al. Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease. Brain Res. 2010; 1328: 139-51. [DOI:10.1016/j.brainres.2010.02.031] [PMID]
23. Kim GH, Kim JE, Rhie SJ, Yoon S. The role of oxidative stress in neurodegenerative diseases. Exp Neurobiol. 2015; 24(6): 804-12. doi:10.5607/en.2015.24.4.325 [DOI:10.5607/en.2015.24.4.325] [PMID] [PMCID]
24. Sarrafchi A, Bahmani M, Shirzad H. Oxidative stress and Parkinson's disease: New hopes in treatment with herbal antioxidants. Curr Pharmaceut Design. 2016; 2(2): 161S-70S. [DOI:10.2174/1381612822666151112151653] [PMID]
25. Bhat A, Dar K, Anees S, Zargar M. Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight. Biomed Pharmacother. 2015; 7(33): 101-10. [DOI:10.1016/j.biopha.2015.07.025] [PMID]
26. Montine TJ, Neely MD, Quinn JF, et al. Lipid peroxidation in aging brain and Alzheimer's disease1, 2. Free Radical Biology and Medicine. 2002; 33(5): 620-6. [DOI:10.1016/S0891-5849(02)00807-9]
27. Lee SE, Hwang HJ, Ha J-S, Jeong H-S, Kim JH. Screening of medicinal plant extracts for antioxidant activity. Life Sci. 2003; 73(2): 167-79. [DOI:10.1016/S0024-3205(03)00259-5]
28. Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radical Biol Med. 2001; 30(4): 433-46. [DOI:10.1016/S0891-5849(00)00498-6]
29. Soobrattee MA, Neergheen VS, Luximon-Ramma A, Aruoma OI, Bahorun T. Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat Res. 2005; 579(1): 200-13. [DOI:10.1016/j.mrfmmm.2005.03.023] [PMID]
30. Sultana R, Ravagna A, Mohmmad‐Abdul H, Calabrese V, Butterfield DA. Ferulic acid ethyl ester protects neurons against amyloid β‐peptide (1-42)‐induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochemist. 2005; 92(4): 749-58. [DOI:10.1111/j.1471-4159.2004.02899.x] [PMID]
31. Mansouri MT, Farbood Y, Sameri MJ, Sarkaki A, Naghizadeh B, Rafeirad M. Neuroprotective effects of oral gallic acid against oxidative stress induced by 6-hydroxydopamine in rats. Food Chem. 2013; 138(2-3): 1028-33. [DOI:10.1016/j.foodchem.2012.11.022] [PMID]
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