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J Adv Med Biomed Res 2025, 33(157): 10-10 |
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Seyedzadeh A, Tohidi M R, Mohammadi Kamalvand M. The Effect of Vitamin A and Corticosteroid in Reducing Kidney Scars in Children with Acute Pyelonephritis: A Clinical Trial Study. J Adv Med Biomed Res 2025; 33 (157) :10-10
URL: http://journal.zums.ac.ir/article-1-7465-en.html
URL: http://journal.zums.ac.ir/article-1-7465-en.html
1- Department of Pediatrics, School of Medicine, Dr. Kermanshahi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Department of Pediatrics, School of Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Department of Pediatrics, School of Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran ,mehrnoshmohammadi.k67@gmail.com
2- Department of Pediatrics, School of Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Department of Pediatrics, School of Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran ,
Abstract: (17 Views)
Background and objective: The effect of vitamin A and Corticosteroids in reducing kidney scars in children with acute Pyelonephritis (PN).
Materials and Methods: Forty-five children with PN were assigned to three groups of vitamin A (n= 15), Corticosteroid (n= 15) and placebo (n= 15). In addition to standard treatment for all patients, the first group received vitamin A once daily with 25,000 units for children under one year and 50,000 units for one year of age and older children during three days of hospitalization intravenously. The second group received Corticosteroids (dexamethasone) daily 0.15 mg/kg/day in two divided intravenous doses (25) during three days of hospitalization. The placebo group received normal saline as an injection. Follow-up continued for six months.
Results: The recovery rate of abnormal lesions in the vitamin A, Corticosteroid and placebo groups was 46.7%, 6.7% and 26.7% respectively (P-Value=0.016). Also, the results of 99mTc-dimercaptosuccinic acid (DMSA) before and after intervention was statistically significant only for the group receiving vitamin A, so that 46.7% of the total 66.7% patients with abnormal lesions in the first 99mTc-DMSA scan had improved after the intervention in the the second 99mTc-DMSA scan (P-Value =0.001).
Conclusion: Vitamin A may be effective in reducing kidney scars in children with APN.
Materials and Methods: Forty-five children with PN were assigned to three groups of vitamin A (n= 15), Corticosteroid (n= 15) and placebo (n= 15). In addition to standard treatment for all patients, the first group received vitamin A once daily with 25,000 units for children under one year and 50,000 units for one year of age and older children during three days of hospitalization intravenously. The second group received Corticosteroids (dexamethasone) daily 0.15 mg/kg/day in two divided intravenous doses (25) during three days of hospitalization. The placebo group received normal saline as an injection. Follow-up continued for six months.
Results: The recovery rate of abnormal lesions in the vitamin A, Corticosteroid and placebo groups was 46.7%, 6.7% and 26.7% respectively (P-Value=0.016). Also, the results of 99mTc-dimercaptosuccinic acid (DMSA) before and after intervention was statistically significant only for the group receiving vitamin A, so that 46.7% of the total 66.7% patients with abnormal lesions in the first 99mTc-DMSA scan had improved after the intervention in the the second 99mTc-DMSA scan (P-Value =0.001).
Conclusion: Vitamin A may be effective in reducing kidney scars in children with APN.
Type of Study: Clinical Trials |
Subject:
Clinical Medicine
Received: 2025/01/28 | Accepted: 2025/05/1 | Published: 2025/05/29
Received: 2025/01/28 | Accepted: 2025/05/1 | Published: 2025/05/29
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