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Showing 2 results for حجتی

Zahra Rabiei, Mostafa Gholami, Mohammad Reza Hojjati,
Volume 22, Issue 92 (5-2014)
Abstract

Background and Objective: Alzheimer’s disease (AD) is a degenerative disorder that leads to progressive cognitive decline. The memory dysfunction of AD has been associated with a cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert (NBM). This study investigated the effect of ethanolic extract of Cyperus rotundu tubers (CRT) on motor activity in NBM-lesioned rat model of AD and intact rats. Materials and Methods: In this experimental study 49 Wistar rats were divided into 7 groups. For this purpose, Wistar rats received bilateral electric lesions of the NBM. The control and sham groups received distilled water while NBM-lesioned group received CRT extract for 20 days with doses of 100 and 200 mg/kg. Intact rats received CRT extract for 20 days without any surgery. The motor activity was assessed with Rotarod apparatus. Data were analyzed using one- way Anova and LSD test. Results: Use of ethanolic extract of CRT for 20 days improved motor activity in NBM-lesioned rats that received extract with a dose of 100 mg/kg. Ethanolic extract of CRT in the intact rats for 20 days significantly reduced motor activity when compared with the control group. Conclusion: The results of this study suggest that ethanolic extract of CRT is useful in NBM-induced lesion rats via inducing some changes in acetylcholine levels in the brain.


Zahra Pakseresht, Pirasteh Norouzi, Vida Hojati, Hamid Moghaddam Kalalian ,
Volume 24, Issue 107 (8-2016)
Abstract

Background and Objective: Diabetes as one of the most prevalent and chronic diseases is dramatically increasing worldwide and Iran is no exception. Diabetes mellitus with oxidative stress and overproduction of reactive oxygen species (ROS) can cause metabolic disorders and deactivate the antioxidant defense. Palmatine hydrochloride has anti-diabetic and antioxidant effects among its various pharmacological effects. This study was done to prevent diabetes-induced oxidative stress.

Materials and Methods: In this experimental study, 32 male wistar rats were randomly allocated to 4 groups of control, palmatine-treated non-diabetic, diabetic, and palmatine-treated-diabetic. Diabetes was induced by streptozotocin (STZ) intraperitoneal injection (55mg/kg). Palmatine hydrochloride was administered S.C at the doses of 10 mg/kg/day 1 week after STZ injection for a period of 6 weeks. Blood samples were taken from the tail vein 1,3,5 and 7 weeks after STZ injection to measure blood glucose levels. After the end of the experiment, blood samples were taken from the heart of the mice and glucose, insulin, lipid peroxidation (MDA) nitrite levels and superoxide dismutase activity were evaluated as biomarkers of oxidative stress. Data were analyzed using Prism-5, one-way ANOVA and Tukey tests.

Results: The results revealed that diabetes increases the level of glucose, malondialdehyde, and nitrites while reduces insulin and superoxide dismutase activity in the diabetic mice compared to the control group. Improvement of oxidative stress was evident in palmatine hydrochloride administered diabetic rats.

Conclusion: This study showed that palmatine treatment can reduce blood sugar and oxidative stress in STZ induced diabetic rats.



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