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Showing 5 results for رودباری

Nasim Hayati Roodbari, Kazem Parivar, Alireza Badiei, Smaneh Zolfaghari Barogh,
Volume 22, Issue 91 (4-2014)
Abstract

Background and Objective: Due to inclusion of nano titanium dioxide in substances such as sunscreens and detergents which may be used by pregnant mothers and regarding that the studies on the effects of such substances have not yet been clearly elucidated, therefore, we conducted this study to investigate the effect of TiO2 on forelimb buds in mouse embryos. Materials and Methods: In this study, five groups of forelimb buds including control, sham, experimental group 1 (using a dose of 30 mg/kg), experimental group 2 (using a dose of150 mg/kg) and experimental groups 3 (using a dose of 500 mg/kg), were investigated. On day 11 of gestation, control group without the effect of TiO2, sham group with injection of deionized water as TiO2 solvent and experimental groups with injection of TiO2 (10 nm particles) with doses of 30, 150 and 500 mg/kg mouse weight were examined. Then, on day 15 of gestation, embryos were removed from the mothers’ body and their forelimb buds were amputated. Results: The findings revealed a significant increase in doses 30 and 150 mg/kg in the total length of limb bud, skin thickness, the number of mesenchymal cells in fingers, degenerating chondrocyte cells in arm, and a significant decrease in the number of proliferating chondrocyte cells in arm, mesenchymal cells in palm and wrist, mitotic dividing mesenchymal cells in fingers and red blood cells in fingers. Meanwhile, it was found that the dose of 500 mg/kg led to a significant decrease in the total length of limb bud, skin thickness of arm, number of proliferating chondrocytes in arm, red blood cells in fingers and mesenchymal cells in palm and wrist. Conclusion: The findings of this study revealed decreasing and increasing effects of cytotoxicity of TiO2 nanoparticles on the growth of forelimb bud in mouse embryos under in vivo conditions.


Raheleh Moradi, Leida Moghaddam-Banaem, Shahla Roudbar Moammadi, Mohammad Asghari, Maryam Roudbary,
Volume 22, Issue 93 (6-2014)
Abstract

Background and Objective: Vulvovaginal Candidiasis is one of the most common vaginal infections which can be related to the use of IUD. Determination of candida species which lead to vulvovaginal candidiasis is very important for proper treatment. This study aims to assess the effect of IUD insertion on Candida fungal flora in cervicovaginal smears. Materials and Methods: This prospective longitudinal study was performed in health centers affiliated to Tehran University of medical sciences from Nov. 2011 through Sep. 2012. 95subjects who had selected Copper T-380-A IUDs as a contraception and had no history of local or systemic antibiotics or antifungals use during the last 2 weeks, were considered eligible candidates. After obtaining the clients’ written consent, cervicovaginal swab specimens were collected and cultured on Sabouraud Dextrose Agar, before and 3 months after IUD insertion. Produced white colonies were cultured on Chrom Agar Candida. Then, species were differentiated by different colors. The SPSS 16 was used to analyze the collected data. P-value <0.05 was considered significant. Results: The occurrence of candidiasis was significantly increased 3 months after IUD insertion (25% vs 11.6%, P= 0.007). The most common identified species before and after IUD insertion was c.albicans and then c.glabrata. Conclusion: Because of the increase in the prevalence of candidiasis after IUD insertion, further investigations with larger samples and variety of settings are needed to evaluate the exact health risks or benefits of IUDs. Increase in the prevalence of candida glabrata as one of the resistant species to azole drugs is of importance.


Parisa Hassani , Parichehr Yaghmaei , Nasim Hayati Roodbari ,
Volume 24, Issue 102 (3-2016)
Abstract

Background and Objective: Antioxidants along with other active biological effects of Green Tea and Zataria multiflora boiss deserve paramount consideration. This study was an attempt to evaluate the effects of Green Tea and Zataria multiflora boiss on passive avoidance learning and hippocampus neurogenesis in Wister male rats.

Materials and Methods: Upon assigning the rats to three groups of control (intact), sham and experimental, the sham group received 1 cc of distilled water by infusion for 8 weeks, whereas the experimental group received 0.5 cc of green tea and 0.5 cc of Zataria multiflora boiss infusion, with concentration of 0.04 g/ml via oral gavage daily for 8 weeks. Subsequent to administration of behavioral test (Passive avoidance learning), density of neurons in the rats’ hippocampus was microscopically assessed and one-way ANOVA test was implemented for data analysis.

Results: Green tea and Zataria multiflora boiss significantly enhanced memory recall in animals. In the meantime, over histologic analysis, augmentation in the number of neurons in the hippocampus regions was observed.

Conclusion: These findings verify the beneficial remedial effects of green tea and Zataria multiflora boiss on improvement of memory, neurogenesis of CA3 regions and dentate gyrus in rat hippocampus. 


Seyedeh Hamideh Husseini Zandabadi, Nasim Hayati Roodbari, Kazem Parivar,
Volume 24, Issue 104 (5-2016)
Abstract

Background and Objective: Sesame is one of the plants with many applications including production of sesame oil, ground sesame seed, sweets and bread in food industry. Alongside, it is used to boost strength and body foundation due to its nourishing properties. Whereas the likelihood of teratogenicity for this seed has been discussed during the pregnancy, the present study was carried out to investigate the possible effects of sesame seeds on the Oogenesis.

Materials and Methods: In this expermental study, the mice were retained under appropriate laboratory conditions and were divided into five groups of control, sham, empirical 1, 2, and 3. The mice of the control group were supplied merely with water and special mouse food, while the mice of sham group were given 0.5 cc of distilled water daily for 10 days. The mice of three empirical groups 1, 2 and 3 were supplied with doses of 0.0818, 0.1636 and 0.818 (mg/Kg of body mass) sesame, respectively, mixed with 0.5 cc of distilled water by oral gavage. The mice in all groups were dissected after the completion of the gavage and the texture of their right[d1]  and left ovaries was separated and examined after the process of alcohol supply, molding, shredding as well as painting.

Results: Following the administration of sesame seed, the side effects were investigated such as increase in the number of follicle types, increase in the diameter and number of primitive and primary follicles, decrease in the diameter of other follicles, increase in the length and the diameter of ovaries and increase in the number of yellow bodies.

Conclusion: The above results assert the harmful effect of sesame seeds on the ovary[d2]  and on the process of Oogenesis.



Parvin Khodarahmi, Nasim Hayati Roodbari, Kazem Parivar, Marjan Sadeghian,
Volume 24, Issue 107 (8-2016)
Abstract

Background and Objective: Iron oxides nanoparticles have numerous applications in medical industry. Nanoparticles are particles with 100 nm in diameter. Despite their various applications, toxic effects of Iron oxide nanoparticles call for supplementary investigations. In this study, the toxic effect of iron oxide nanoparticles on lung development in fetal mice was examined.

Materials and Methods: Using in vivo technique, the mice were allocated to one of the following groups: the control group without the effect of nano iron oxide, sham group with injection of distilled water and experimental groups with low doses (10, 30 and 50 µg /kg) and high doses (10, 30 and 30 mg/kg) of nano iron oxide with 20 nm in diameters injected intraperitoneally on day 9 of pregnancy. On day 16 of pregnancy, embryos were removed and the lung tissue sections were assessed.

Results: The findings showed a significant decrease in the length of the fetus with 30 and 50 mg/kg doses and a significant decrease in the fetal weight and number of primitive bronchioles with 10, 30 and 50 mg/kg. Results  also showed a significant increase in lung weight and lung length with doses of 30 and 50 µg/kg, a significant increase in the number of alveolus with doses of 10, 30, 50 µg/kg and 10 mg/kg and a significant increase in the number of necrotic cells  with doses of  30 and 50 mg/kg.

Conclusion: Iron oxide nanoparticles showed dual effects. It is asserted throughout this study that fetal lung development increases at low doses and necrotic effect increases with high doses.



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