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Showing 4 results for مهاجر

Sima Hashemipour, Bagher Larijani, Rza Baradarjalili, Mohammadreza Mohajeri,
Volume 11, Issue 43 (Jun 2003)
Abstract

Background: Pharmacotherapy of acromegaly has been successful in recent years. The therapeutic efficacy of long-acting sandostatin in the treatment of acromegaly has been established in multiple studies. In this report, we investigated the effectiveness of multiple injections of sandostatin and its acting period in Tehran in 2001.
Materials and Methods: In this Quasi-experimental study five diagnosed patients with acromegaly after hypophysectomy were treated with sandostatin LAR and followed up for at least 63 days after injection. After octreotide test, a dose of 30 mg sandostatin was prescribed for 3 injections. Frequency of mean daily growth hormons (GH) less than 5µg/L were compared after the first and the third injections. Then acting time of the drug was assessed. The efficacy of 30 and 40 mg doses were compared in 3 cases.
Results: There was no relationship between response rate to octreotide and sandostatin. Frequency of GH<5µg/L after the third injection was higher than that of the first one (P<0.01). Therapeutic effect of the drug continued for 42 days after the treatment in responding patients.
Conclusion: Octreotide test (with single dose injection) is not a good method for prediction of patients' response to treatment. Measuring GH after multiple injections is a better method for this purpose. Drug injection interval should be determined separately for each patient.

Dr Parvaiz Mohajeri, Dr Akbar Tavakoli, Dr Sharareh Moghim,
Volume 17, Issue 66 (5-2009)
Abstract

Background and Objective: Drug resistance to tuberculosis is continuously increasing and is a significant threat to tuberculosis control programs because afew effective drugs are present against Mycobacterium tuberculosis. Although isoniazid (INH) is the most effective drug against tuberculosis, resistance to this drug also develops readily. Mutations in katG, specially the Ser315Thr substitution, are responsible for isoniazid resistance in a large proportion of patients with tuberculosis. However, the frequency of the katG Ser315Thr substitution varies among population samples. This study provided molecular characterization of isoniazid resistance of M. tuberculosis strains and extended our knowledge about molecular basis of M. tuberculosis drug resistance that is widely applicable for rapid drug resistance detection. Materials and Methods: Using 1% proportional method, the sensitivity of 126 strains isolated from patients in Isfahan and Tehran to isoniazid was determined. The katG mutations in codon 315 associated with isoniazid resistance among isoniazid resistant isolates was determined by PCR-RFLP. In this way, 355 bp PCR products were digested by MspI. Results: Out of 126 isolates of M. tuberculosis, 32 (25.4%) strains were determined as INH resistant. Resistance rate was 22.6% (19 strains) in Isfahan and 31% (13 strains) in Tehran. Overall, 72% of isoniazid-resistant isolates could be identified by analysis of just katG 315 loci. Conclusion: The PCR-RFLP using MspI restriction enzyme that detects katG Ser315Thr substitution could be identified in 72% of isoniazid-resistant strains. Elucidation of the molecular characterization of isoniazid resistance in M. tuberculosis has led to the development of different genotypic approaches to the rapid detection of isoniazid resistant in clinical isolates.


Ramezan Fallah, Sadaf Farhadi, Koroush Amini, Mansour Mohajeri,
Volume 19, Issue 75 (4-2011)
Abstract

Background and Objective: Depression has been assumed as a prevalent disorder of the era. Depression cannot be attributed to a particular social class. Factors such as incompatible situations may lead to mental disorders and affect physical immunity. This study was carried out to investigate the prevalence of depression among the staff of Zanjan University of Medical Sciences.
Materials and Methods: This study was of cross-sectional type study whereby 693 subjects were selected through classified randomized sampling. The rate of depression incidence was obtained using Standard Beck Questionnaires. The data was analyzed by Chi-2 tests and cohesion indexes of Kramer and Gama were also used.
Results: According to the results of this study 40% of the personnel were suffering from depression. They were identified as 23% with low depression, 13% with moderate depression, and 4% with severe depression. A significant correlation was found between depression and education level, type of settlement, and city where they worked.
Conclusion: Regarding the widespread prevalence of depression among the staff, planning and organization of consultation sessions by the authorities is suggested.


Mehrdad Modaresi, Mohsen Mohajer,
Volume 23, Issue 101 (8-2015)
Abstract

Background and Objective: Heat stress is one of the most important environmental pressures which can reduce sexual performance. Garlic has been proposed for increasing resistance against stress. This study dealt with the effects of garlic hydroalcoholic extract on reproductive hormones in male mice under heat stress.

Materials and Methods: Fifty male mice were studied in five groups (n=10). The experiment consisted of a control group (normal situation without receiving extract) and four treatment groups that were kept under heat stress (36±3C) four hours a day (on site) and received 0, 200, 400, and 800 mg/kg of body weight garlic extract in drinking water for thirty days. Blood samples were taken at the end of the experiment and testosterone, FSH and LH hormones were measured. After dissection and removal of the testicles, changes in spermatocytes were evaluated. The obtained data were analyzed using SPSS software.

Results: Heat stress reduced all sexual hormones significantly (p<0.05) in group Zero but testosterone and LH levels increased in groups receiving 400 and 800 mg/kg doses of garlic extract. FSH levels increased significantly in groups receiving doses of 200, 400, and 800 mg/kg, which were similar to the control group. The number of primary spermatocytes in groups Zero reduced compared to the control, but significantly increased at 200, 400 and 800 doses. 

Conclusion: Heat stress can reduce reproductive hormones and spermatogenic cells in male mice and garlic extract can compensate for this loss and play a moderating role on the reproductive potential under heat stress.

 



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