The 2019 Coronavirus disease pandemic (COVID-19) has spread to over two hundred countries worldwide, affecting > 170 million people and causing >3,500,000 deaths (May 29, 2021). Severe COVID-19 disease mostly disturbs the respiratory system, but gastrointestinal symptoms, including vomiting, nausea and diarrhea, are also present. Herein, we are reporting a COVID-19 patient with acute pancreatitis (AP) in Zanjan, Iran. . This patient showed acute pancreatitis as a COVID-19-related complication, emphasizing the importance of evaluating pancreas-specific plasma amylase levels in patients with COVID-19 and intestinal cramping.