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Marjan Sharifi Nasab, Hamide Yazdimoghaddam, Seyedeh Tahereh Mohaddes, Mohammad Hasan Rakhshani,
Volume 30, Issue 138 (January & February 2022)
Abstract

Background and Objective: Colorectal cancer (CRC) is a highly prevalent malignancy leading to death across the world. However, patient survival is greatly affected following a diagnosis of diabetes. The purpose of this research was to study the correlation between diabetes and controlling risk factors with the survival rate of colorectal cancer patients.
Materials and Methods: This retrospective follow‐up study was done on 356 patients with colorectal cancer, who had been diagnosed during 1999-2013. Notably, the patients were selected using systematic random sampling. The patients were allocated into two groups according to the history of diabetes and its absence. The survival rate of the patients was assessed during the follow-up period up to 2018.
Results: In colorectal cancer patients, the diabetes prevalence was 11%. The mean survival rate in patients with CRC and non-colorectal non-diabetic was 5.541±0.227 years and in diabetic patients was 0.508 ±5.246 years. No significant difference was apperceived in the survival rate of the diabetic and non-diabetic patients (P = 0.57). The risk of mortality in patients with CRC who were not treated with insulin increased and their survival decreased (P= 0.05). In metastatic stage of lymph nodes, it was 0.314 higher in patients with the metastasis to distant regions (P = 0.000).
Conclusion: Based on the results, training diabetic patients regarding effective therapies in controlling risk factors, hyperglycemia, and screening for rapid diagnosis of CRC are essential to improve health and increase survival rate in diabetic patients.


Hamideh Yazdimoghaddam, Fatemeh Zahra Karimi, Elham Navipour,
Volume 31, Issue 147 (July & August 2023)
Abstract

Background and Objective: Very often the patients who undergo laparoscopic surgery suffer from shoulder pain (SP). As a result, different studies have been conducted to mitigate shoulder pain following laparoscopic surgery. This systematic review aims to investigate the efficacy of different interventions in mitigating laparoscopy-induced SP.
Materials and Methods: In this systematic review, relevant articles were included using ISI, PubMed, MEDLINE, etc., from 2009 to 2020. Medical Subject Headings (Mesh) of Laparoscopic Surgical Procedures, Surgery Laparoscopic, Laparoscopic Assisted, Shoulder Pain, randomized controlled trial, and clinical trial were searched for eligible studies. Random effect model and standardized mean difference (SMD) index were applied to combine the studies and perform a meta-analysis.
Results: A total sample of 11,024 was obtained for 10 selected studies. Results from intraoperative intervention demonstrate that the mean VAS (visual analog scale) scores were 1.46(CI 95%: -0.32, 3.24) and 1.87(CI 95%:0.79, 2.94) in the intervention and control groups, respectively six hours after surgery. The mean VAS scores were 2.06(CI 95%: 0.91, 3.20) and 2.35 (CI 95%: 0.57, 4.13) in the intervention and control groups, respectively, twelve hours after surgery. 24 hours following surgery; the mean VAS scores were 0.96(CI 95%: -0.21, 2.13) and 1.27(CI 95%: 0.33, 2.21) in the intervention and control groups, respectively.
Conclusion: The results of this meta-analysis demonstrate that intraoperative interventions, such as Peritoneal Suction Drainage, injection of Intraperitoneal Hydrocortisone with Bupivacaine, and warm and humidified insufflation carbon dioxide, can reduce the severity of SP in patients with LS. In addition, clinical trials with different interventions are needed to compare the efficacy and find effective interventions for SP management in patients with LS.



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