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Showing 3 results for Lactate Dehydrogenase
The Effect of Fe4NiO4Zn Nanoparticles on some Liver Factors in Wistar Rats
Rashed Golmohammadi , Zahra Hooshmandi, Mahbobeh Setorki,
Volume 23, Issue 101 (8-2015)
Abstract

Background and Objective: Fe4NiO4Zn nanoparticles are used in nano technological applied arenas. Given the importance of liver in detoxification of the body, this study dealt with the toxicity effect of Fe4NiO4Zn nanoparticles on changes of hepatic factors

Materials and Methods: Twenty four Wistar rats were randomly assigned to three groups: A control group(1) and two treatment groups (2, 3) which received 0.5cc of saline, 0.5cc of solution containing 100, 200 ppm Fe4NiO4 for 7 successive days, respectively. Then, parameters such as lactate dehydrogenase (LDH), alkaline phosphatase (ALP), transferrin (TR) and albumin were measured on days 2, 7 and 14 after the treatment.

Results: Mean TR levels, on day 7 after the intervention in the group of Fe4Nio4Zn (200ppm) and on day 14 of the study in both groups of  Fe4Nio4Zn (100,200ppm) significantly decreased. Likewise, on day 2 of the study the average of LDH in the group of Fe4Nio4Zn (100ppm) and on days 7 and 14 in both groups of Fe2Nio4Zn(100,200ppm) significantly decreased. Mean ALP showed a significant decrease on day 2 after the intervention in both treatment groups as compared with the control group.

Conclusion: Findings concerning reduced hepatic factors throughout this study assert that the body can gradually eliminate Fe4Nio4Zn nanoparticles after the injection. On the other hand, the toxic effects of these elements are eliminated either as a consequence of the loss of the properties of nanoparticles after the administration or due to a state of hepatocyte tolerance.


Study of some Biochemical and Hematological Parameter Changes in Rats Induced by Intraperitoneal Injection of Colloidal Silver Nanoparticles
Hossein Hamzehei, Hamed Alizadeh, Mohsen Ajalli, Katayoun Rahmani,
Volume 25, Issue 108 (3-2017)
Abstract

Background and Objective: Today, silver nanoparticles are used extensively in various fields, especially in the control of bacterial infections. However, the toxicity of silver nanoparticles is a very important concern in their use. The aim of this study was determining the effect of the intraperitoneal injection of colloidal silver nanoparticles on biochemical and hematological parameters in rats.

Materials and Methods: In this experimental study, 21 adult female rats were randomly divided into 7 groups. Group 1 was sham. Group 2 was a control group and group 3 to 7 were case groups that were treated with 5, 10, 20, 40 and 80 ppm of silver nanoparticles, respectively. Mice treated for 10 days. On the eleventh day the rats were killed by diethyl ether anesthesia. Blood samples were taken from the heart. Then the biochemical and hematological parameters and lactate dehydrogenase (LDH) levels evaluated.

Results: The results showed no significant changes in biochemical factors except triglycerides (TG), which showed a significant decrease in high concentrations of silver nanoparticles (p<0.05). Significant changes were observed at concentrations higher than 20ppm of silver nanoparticles in blood, including: reduction in the amount of white blood cells, increase in number of platelets, slightly decreased hemoglobin and hematocrit (p<0.05). At 80ppm concentration of silver nanoparticles the serum level of lactate dehydrogenase fell sharply.

Conclusion: Low concentrations of silver nanoparticles (such as injecting it inside the peritoneum) has no effect on biochemical parameters in rats. By studying any other possible side effects, it may be safe to use in various industries.


Relationship between Severity of Primary Lung Involvement with Erythrocyte Sedimentation Rate and Lactate Dehydrogenase in Patients with COVID-19 in Yazd
Mohammad Cheraghi Pour, Fatemeh Khaleghi, Nasim Namiranian, Kazem Ansari, Mehrdad Mansouri, Nastaran Injinari, Fatemeh Aghaeimeybodi,
Volume 30, Issue 140 (5-2022)
Abstract

Background and Objective: Measurement of inflammatory markers and lactate dehydrogenase (LDH) may contribute to the evaluation of lung involvement severity. This study aimed to evaluate relationship between severity of primary lung involvement with highest level of erythrocyte sedimentation rate (ESR) and LDH in patients with COVID-19.
Materials and Methods: This descriptive-analytical study was conducted on 123 patients with COVID-19 in Shahid Sadoughi Hospital. Data including age, gender, ESR (mm/h), LDH (U/L), and high-resolution Computed Tomography scan (HRCT) findings and hospitalization ward were extracted from medical records. The regression model was used to determine the relation between HRCT findings with LDH and ESR.
Results: Mean LDH, ESR, and HRCT findings were 508.41±224.65, 52.23±29.56, and 37.17± 22.18 respectively. A significant relation was seen between HRCT findings with highest level of LDH and ESR (P=0.001). A significant relation was observed between the highest levels of ESR and HRCT findings, regarding age, gender, and hospitalization wards (P<0.01). There was a significant relation between the highest level of LDH and HRCT findings regarding age group and hospitalization wards (P<0.01).
Conclusion: A significant relation was seen between HRCT findings and highest levels of ESR and LDH in patients with COVID-19. Therefore, it seems that assessment of laboratory findings such as LDH and ESR can be helpful as cost-effective markers instead of chest CT scan for predicting the severity of lung injury when the CT scan report is controversial. The relation between HRCT findings with LDH and ESR were affected by age and hospitalization ward. However, more studies should be conducted in this regard.


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