Showing 7 results for Persian Medicine
Saeed Sardari, Ahmadreza Mobaiend, Leila Ghassemifard, Koorosh Kamali, Narjes Khavasi,
Volume 29, Issue 133 (2-2021)
Abstract
Background and Objective: SARS COV-2 is a worldwide pandemic disease. There is currently no effective cure for this virus, but some types of herbs can be a good choice for reducing its symptoms. There are some reports that Thymus Vulgaris has a high antioxidant compounds effective in strengthening the immune system, as well as anti-virus effects to reduce the respiratory symptoms. Therefore, we speculated that Thymus Vulgaris could be useful for reducing some of the symptoms in patients suffering from COVID- 19.
Materials and Methods: First, thyme essential oil was prepared and a questionnaire regarding the patients’ symptoms was designed. Then, 83 patients with COVID-19 were randomly selected and divided into control group and thyme receiving group (TRG). The questionnaire was completed and emphasized to consume 5 mL of the syrup or essential oil three times per day. Finally, one week after the first visit, the questionnaire was completed again to determine the effects of thyme on the mentioned symptoms. Finally, the test results were reviewed and reported.
Results: The results one week after taking thyme showed that, the fever (p<0.027), dizziness (p<0.003), cough, dyspnea, muscular pain, headache, anorexia, weakness and lethargy, fatigue, and chest wall pain were significantly reduced (p<0.001). Also, BUN (p<0.004), neutrophil count (p<0.001), and calcium (p<0.034) decreased but, lymphocyte count was increased significantly (p<0.001).
Conclusion: Thyme plant which has high antioxidant properties, strengthens the immune system, and induces the antiviral effect could reduce the symptoms of coronavirus; therefore, it is recommended for reducing the symptoms of COVID-19.
Fariba Mahmoodpoor, Seyed Hojjat Hosseini, Elham Ahmadian, Mohammadreza Ardalan, Koorosh Kamali, Sepideh Zununi Vahed, Saeed Sardari, Narjes Khavasi,
Volume 31, Issue 144 (1-2023)
Abstract
Background and Objective: Increment in cancer prevalence and subsequent need for chemotherapy leads to distinct kidney-related diseases such as acute kidney injury (AKI). Cisplatin is a common chemotherapeutic agent that has been used in many cancers; however, it can damage renal cells. Capparis spinosa is an important therapeutic plant in Persian medicine that encompasses high amounts of bioactive antioxidant components. The current study aimed to evaluate the nephroprotective effects of Capparis spinosa seed hydroalcoholic extract (CSSE) against cisplatin-induced nephrotoxicity in vivo through histopathological evaluation.
Materials and Methods: Forty Sprague Dawley rats weighing within the range of 230±20 gr were randomly divided into eight groups including sham, a single-dose cisplatin intraperitoneally (IP) injected group (7 mg/kg), toxic dose CSSE (200 mg/kg) group, and groups with cisplatin 7mg/kg IP and different doses of CSSE. Histopathological changes in the kidney tissues were quantified by the image-J program and analyzed by statistical methods.
Results: Cisplatin-induced glomerular and tubular injuries in the kidney tissue. A single-dose cisplatin decreased the glomerular area and Bowman's capsule area, increased Bowman's space, and induced tubular loss of brush borders, tubular dilatation, tubular cast formation and tubular necrosis. All of the changes were reversed by CSSE significantly.
Conclusion: Post-CSSE (50 and 100 mg/kg) treatment could protect against cisplatin-induced nephrotoxicity in vivo. More clinical studies are needed to confirm its protective effects on the prevention of kidney injury in chemotherapy receiving patients.
Dr Narjes Khavasi, Dr Mahdi Tavakolizadeh, Dr Saeed Sardari, Msc Leila Ghassemifard, Dr Mina Reshadatifar, Dr Milad Darkhori, Dr Mina Mohebian, Dr Fakhri Haghi, Dr Saeid Amanloo, Dr Kamyar Mansori,
Volume 32, Issue 152 (6-2024)
Abstract
Background & Objective: Capparis spinosa is a plant belonging to the genus Capari which is important for medicinal purposes. It is also known as a multipurpose plant in Persian medicine. In this study, we searched for natural active ingredients in mouthwash for immunocompromised patients and examined the antifungal plus antibacterial properties of the hydroalcoholic extract of the root of the Capparis plant against Streptococcus mutans (S. mutans) PTCC 1683 and Candida albicans (C. albicans) ATCC-10231 was investigated.
Materials & Methods: Ethanol extracts of plant roots were extracted by the percolation method. The diameter of the growth inhibition zone of C. albicans and S. mutans extracts was measured using the well plate method. Minimum inhibitory concentrations (MICs) were calculated for bacterial and fungal strains. In addition, the minimum sterilization concentration (MBC) and minimum sterilization concentration (MFC) of the extract were investigated using the broth microdilution method. The results were compared with an antibacterial and antifungal drug of 0.2% chlorhexidine nystatin.
Results: The results for both pathogens revealed that the diameter of the growth inhibition zone increased with elevation of the extract concentration. The MIC and MBC of S. mutans extract were 62.5 and 62.5 mg/ml, compared to 0.39 and 0.39 mg/ml for chlorhexidine. The MIC and MFC of the plant against the fungus C. albicans were 7.812 and 31.25 mg/ml, compared to 0.25 and 1.25 μg/ml for nystatin.
Conclusion: The ethanol extract of the Caparis plant had an antifungal effect on C. albicans and an antibacterial effect on S. mutans. However, the inhibitory and lethal effects against bacterial and fungal strains were lower than those of nystatin and chlorhexidine.
Dr Saeed Dadashi, Dr Parvin Mansouri, Dr Asghari Majid, Dr Farshi Susan, Dr Fatemeh Aliasl,
Volume 32, Issue 154 (10-2024)
Abstract
Background & Objective: Hand contact dermatitis, with a one-year frequency of up to 10% and a lifetime prevalence of nearly 15% in the general population, typically involves inflammation of the dermis and epidermis layers .The aim of this study was to investigate and emphasize the anti-inflammatory properties of flaxseed oil as well as its historical use in traditional medicine, which could help support its potential effectiveness in treating hand eczema and improving the quality of life of patients.
Materials & Methods: The research conducted was a triple-blind, randomized controlled trial involving 68 patients diagnosed with mild to moderate eczema. The participants were assigned to receive either 1 gram of topical flaxseed oil applied twice daily or a control cream, Eucerin, over a period of four weeks. The effectiveness of the treatment was evaluated by measuring the severity of eczema and the quality of life of the patients before and after the intervention. This assessment was carried out using the Hand Eczema Harshness Index (HECSI) and the Dermatology Life Quality Index (DLQI).
Results: Based on the gas chromatography (GC) analysis, the flaxseed oil contained 1.9 grams of linoleic acid per 100 grams of oil. There was no substantial variance in the baseline demographic and clinical characteristics of the two study groups. HECSI and DLQI(14.71 ± 1.89) scores significantly improved in the flaxseed oil group compared to the control group (p=0.001). This effect was particularly pronounced among patients with mild and moderate eczema (p<0.001).
Conclusion: Flaxseed oil can improve eczema indications and quality of life in contact dermatitis patients. However, further research with a larger sample size and comparison to topical steroids is recommended.
Keywords: Flaxseed oil, Dermatitis, Herbal medicine, Persian medicine
Background & Objective: Hand contact dermatitis, with a one-year frequency of up to 10% and a lifetime prevalence of nearly 15% in the general population, typically involves inflammation of the dermis and epidermis layers .The aim of this study was to investigate and emphasize the anti-inflammatory properties of flaxseed oil as well as its historical use in traditional medicine, which could help support its potential effectiveness in treating hand eczema and improving the quality of life of patients.
Materials & Methods: The research conducted was a triple-blind, randomized controlled trial involving 68 patients diagnosed with mild to moderate eczema. The participants were assigned to receive either 1 gram of topical flaxseed oil applied twice daily or a control cream, Eucerin, over a period of four weeks. The effectiveness of the treatment was evaluated by measuring the severity of eczema and the quality of life of the patients before and after the intervention. This assessment was carried out using the Hand Eczema Harshness Index (HECSI) and the Dermatology Life Quality Index (DLQI).
Results: Based on the gas chromatography (GC) analysis, the flaxseed oil contained 1.9 grams of linoleic acid per 100 grams of oil. There was no substantial variance in the baseline demographic and clinical characteristics of the two study groups. HECSI and DLQI(14.71 ± 1.89) scores significantly improved in the flaxseed oil group compared to the control group (p=0.001). This effect was particularly pronounced among patients with mild and moderate eczema (p<0.001).
Conclusion: Flaxseed oil can improve eczema indications and quality of life in contact dermatitis patients. However, further research with a larger sample size and comparison to topical steroids is recommended.
Dr. Parisa Jafari, Dr. Mortaza Mojahedi, Dr. Mojgan Tansaz, Dr. Reza Ilkhani, Dr. Alireza Abbassian, Dr. Hasan Namdar, Dr. Mohsen Saberi Isfeedvajani, Dr. Armin Zareyian, Dr. Hoda Shirafkan, Dr. Abbas Ebadi, Dr. Fatemeh Hakimi, Dr. Meysam Shirzad, Dr. Mahshid Chaichi-Raghimi, Dr. Elham Parsa, Dr. Roshanak Mokaberinejad,
Volume 32, Issue 155 (10-2024)
Abstract
Background & Objective: Traditional medicine use is growing, highlighting the need to standardize diagnostic indices and treatment methods. In Persian medicine (PM), the concept of Mizaj (temperament), especially the Mizaj of major organs such as the heart, brain, and liver, has an important role in diagnosing and treating diseases. The present study aimed to provide a standard tool for diagnosing the warm-cold Mizaj of the liver.
Materials & Methods: A two-stage exploratory study reviewed literature and interviewed PM specialists to identify and construct questions related to liver Healthy Mizaj and Su-e-Mizaj (dystemperament). After assessing the preliminary questionnaire's validity and reliability, the final questionnaire's sensitivity, specificity, and cutoff point were determined. The normal distribution was tested with Kolmogorov-Smirnov. ANOVA, post-hoc tests, and the Mann-Whitney test were used for normal distribution data.
Results: Twenty PM specialists, methodologists, and 245 volunteers participated in this study. The initial questionnaire was regulated based on 180 items in the data pool and after different stages of validity and reliability assessment, 13 items remained. Sensitivity and specificity according to the cutoff point were, respectively, 79 and 74 for the warm liver Mizaj, 80 and 74 for the cold, and so 70 and 77 for the moderate liver Mizaj.
Conclusion: For diagnostic and research purposes, this is the first self-report questionnaire that assesses the warm and cold liver Mizaj in people aged 20 to 60.
Maryam Taghavi Shirazi, Sajjad Sadeghi,
Volume 32, Issue 155 (10-2024)
Abstract
Avicenna's historical insights on digestive health and dermatological symptoms' interrelationship, mainly nocturnal itching, are examined here. In his Canon of Medicine, Avicenna explains a deep relationship between the digestive system and the skin, pointing out that effective waste elimination via the skin is vital for overall wellness. The discussion highlights the significant impact of nocturnal itching on patients with inflammatory skin conditions, such as atopic dermatitis, psoriasis, and chronic urticaria, in studying the roles of skin barrier function and hormonal fluctuations. Furthermore, modern scientific research on the gut-skin axis is integrated to illustrate the continued relevance of Avicenna's therapeutic recommendations, such as addressing internal imbalances, body cleansing, and topical therapies.
Samaneh Sadat Asadi, Parastoo Amiri, Ali Khatib, Mohammad Amin Ebrahimi, Shamim Shahrestani, Fereshteh Ghorat,
Volume 33, Issue 156 (2-2025)
Abstract
Background and Aims: Knee osteoarthritis (OA) is a degenerative joint condition characterized by pain, stiffness, and reduced function, often requiring long-term management. Systemic complications associated with oral NSAIDs have led to increased interest in topical treatments. This study aimed to compare the efficacy of topical Alpinia galanga oil and diclofenac gel in relieving knee OA symptoms.
Methods: The present clinical trial was carried out from December 2021 to May 2022 on clients in health centers of Sabzevar, northeastern Iran. A total of 160 patients aged 45–70 years participated in this study. They were affected by knee OA based on the American College of Rheumatology criteria. Their condition was graded 1 to 3 based on the Kellgren-Lawrence classification system. The patients were randomly assigned to either receive Alpinia galanga L. oil (5–10 drops, bid) or 1% diclofenac gel, applied topically for 28 consecutive days. The findings, including pain severity, joint rigidity, motor acts, exercise ability, and quality of life, were examined at baseline, 14 days, and 28 days post-treatment via the WOMAC questionnaire. Balanced block randomization confirmed equal group assignment, and all patients, researchers, and statistical analysts were blinded to assignments of patients to groups. Data were analyzed using SPSS16, with t-tests and ANOVA employed to determine within-group and between-group differences (P < 0.05).
Results: Out of 160 patients, 81 were given Alpinia galanga oil and 77 received diclofenac gel. Both treatments significantly ameliorated pain acuity, joint rigidity, and motor act scores during the intervention period (P<0.001 for all). Exercise stamina was also fostered significantly in either group (P<0.001) without any significant disparity between treatments (P>0.05). Scores of quality of life were enhanced significantly in the Alpinia galanga oil group (P<0.001), while no significant change was observed in the diclofenac group (P=0.139). Finally, no statistically significant difference was found between groups in initial results suggesting comparable efficacy.
Conclusion: Topical Alpinia galanga oil is as effective as diclofenac gel in alleviating knee OA symptoms, with potential advantages in improving quality of life.