Background and Objective: Glucose Challenge Test (GCT) is done for pregnant women during the week 24-28 of gestation to screen gestational diabetes. In patients with abnormal GCT, a glucose tolerance test (GTT) is performed, and if GTT is impaired, the patient is diagnosed with gestational diabetes. There is some evidence suggesting that abnormal GCT alone is associated with adverse pregnancy outcomes. The aim of this study was to determine the pregnancy outcomes in patients with abnormal GCTs but normal GTT scores. Materials and Methods: In this cohort study, GCT was carried out on 190 pregnant women during the 24th to 28th weeks of gestation. Ninety-five pregnant women with abnormal GCT and normal GTT (study group) and 95 cases with normal GCT (control group) scores entered the study and were compared regarding adverse pregnancy outcomes. Results: The average birth weight in the study and control groups were3397±524gr and 3234±384 gr respectively (P=0.015). Fourteen neonates (14.7%) in the study group and 4(4.2%) in the control group had macrosomia (P=0.013). Frequency of preterm labor was 8 (8.4%) in the cases and 1 (1%) in the controls (P=0.03). Frequency of preeclampsia was 8 (8.4%) in the cases and 1 (1%) in the controls (P=0.03). There was positive family history of diabetes mellitus in 20 (21%) of the cases and 1 (1%) in the controls (P<0.001). Mean BMI changes was 5+1.7 in the study group and 4.3+4.3 in the controls (P<0.004). Conclusion: The prevalence of macrosomia, preterm labor, preeclampsia, family history of diabetes, increasing maternal BMI, and average birth weight were all higher in the pregnant women with abnormal GCT. Thus, due to the high incidence of some unfavorable outcomes, careful follow up women with abnormal GCT but normal GTT appears necessary during pregnancy.

Background and Objective: In the past three decades, the efficacy of using low dose aspirin for preeclampsia prevention has been an important matter in obstetrics research. The purpose of this study was to determine the effectiveness of aspirin in the prevention of preeclampsia in high risk women with abnormal uterine artery Doppler ultrasonography findings.

Materials and Methods: This randomized double blind clinical trial was done in Kowsar hospital in Qazvin, Iran in 2015. All singleton pregnant women at 11-14 weeks of gestation were evaluated by uterine artery Doppler ultrasound and in the case of abnormal findings, were divided into two groups of case (n=50) and control (n=50). The case group received aspirin 80 mg/day and the control group received daily placebos. Both groups were followed up until delivery and pregnancy outcomes including incidence of preeclampsia, intrauterine growth restriction, preterm labor, mode of delivery, 1st and 5^th min Apgar score and neonatal birth weight were recorded. All these data were analyzed with T-Test and Chi-square statistical methods.

Results: Preeclampsia occurred in 6 individuals (12%) in the case group and 12 individuals (24%) in the control group, however this reduction was not statistically significant (P=0.3). No significant difference was observed between the two groups in fetal growth restriction, preterm labor, mode of delivery and Apgar score. Average birth weight in the case group was slightly higher than the control group (P=0.05).

Conclusion: The findings of this study demonstrated that the administration of aspirin from 14 weeks of gestation to women with abnormal Doppler ultrasonography findings could not reduce the risk of preeclampsia.