Showing 5 results for Recurrence
Ejaz Ahmadi, Omid Ghasemkhani, Parisa Dastori,
Volume 11, Issue 42 (3-2003)
Abstract
Background: Bladder cancer is the sixth most common cancer in the world. More than 90% of the bladder cancers are transitional cell carcinoma types and 80% of superficial tumors recur after treatment. In order to determine the recurrence rate and prognostic factors of superficial bladder cancer (SBC), this study was conducted.
Materials and Methods: The information of this historical cohort study was obtained from files of the patients admitted to Shiraz Shahid Faghihi Hospital from 1998-2001. The 76 cases of bladder cancer were diagnosed for the first time as new cases. Variables included in the analysis were age, sex, residential place, job, tumor pathologic grade and stage, BCG therapy, date of diagnosis and time of recurrence. All data were analysed by SPSS-10 software. For assessing prognostic factors of recurrence, the Cox regression multivariate analysis was used and the survival curves were analysed by Kaplan Mayer procedure.
Results: Out of 76 cases of bladder cancer, 72 cases (94.74%) had transitional cell carcinoma and the ratio of male to female was 4.5:1. Twenty-seven (45%) of all SBC cases experienced recurrence. The mean length of follow-up was 14.8 months. In the Kaplan-Mayer survival analysis, the mean length of the recurrence-free period with 95% confidence interval was 24.2 months(18.3- 30.1). For every 10 years of age, the probability of SBC recurrence will increase about 0.5 fold. Also, the probability of recurrence in grade II and III patients was 4.5 and 11 fold higher than in grade I patients, respectively.
Conclusion: Considering the differences between our results and others, we suggest further regional studies to be conducted in this context in order to predict precisely the patient's status. |
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Dr Hosien Sarmadan, Dr Farshideh Didgar,
Volume 15, Issue 61 (12-2007)
Abstract
Background and objective: Lower urinary tract infection is one of the most common infections among young women. The high prevalence of this infection necessitates the administration of appropriate antibiotic and minimizing the treatment period. In this study we examined and compared the effect of single-dose therapy of ciprofloxacin with seven-day therapy in women with lower UTI. Materials and Methods: The study cases comprised of 140 women aged 13-25 years with uncomplicated lower UTI who referred to Vali-Asr hospital in Arak. The patients were randomly assigned into two groups of 70. One group received a single-dose ciprofloxacin (1000 mg) while the other group received a seven-day ciprofloxacin (250 mg twice daily). Urine culture was performed for all the patients three times. In case of primary positive culture the patient would enter the study, and the second culture was carried out to investigate the response to the treatment, whereas the third culture was carried out to study the recurrence. Finally, the results of the two groups were analyzed. Results: Out of 140 patients participating in the study, 23 cases did not respond to the treatment. In the final assessment 14 non-responsive patients belonged to single-dose group while 9 patients were in seven-day therapy group. Conclusion: The research findings showed that there was no significant difference between the two groups (p=0.183) in response to the drug and recurrence. This indicates the equal efficacy of single-dose treatment and one-weak therapy of ciprofloxacin in women with lower UTI.
Parsa Yousefi, Ali Cyrus, Zahra Moghaddasi, Fatemeh Dorreh, Azam Aravand,
Volume 19, Issue 76 (5-2011)
Abstract
Background and Objective: Urinary Tract Infection (UTI) is one of the most common diseases of childhood which may cause serious morbidity. We evaluated recurrence rate of UTI in children without congenital abnormalities who were at the age of 1 month to 12 years old.
Materials and Methods: This cross- sectional study was carried out for three months after the termination of the treatment in order to determine the rate of recurrence and re-infection in children (sex segregationation) at the age of 1 month to 6 years and 6 to 12 years who did not have any anatomical or functional urinary abnormalities at Arak Amir kabir Hospital.
Results: In total, 250 patients (224 girls and 26 boys) were evaluated. 17 girls had recurrences , of whom, 2 cases (%11/7) were under 1 year old ,14 cases (%82/2) had 1 to 6 years old and 1 case (5/8%) was in the 6 to 12 years old group. In the first month there was no relapse and most recurrences occurred through the third month (%65). All recurrences were symptomatic.
Conclusion: Due to low rate of recurrence of urinary infection in our study group, repeated cultures and prophylactic treatments is not recommended in children and infants without underlying congenital renal abnormalities. In such cases, UTI can be prevented by effective trainings.
Hossein Bonakchi, Hamid Farhangi, Habibollah Esmaily, Hassan Boosti, Maryam Forouzannejhad,
Volume 25, Issue 110 (5-2017)
Abstract
Background and Objective: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, accounting for about a quarter of all malignancies. This study aimed to identify the prognosis of patients with relapsed acute lymphoblastic leukemia in Dr. Sheikh Hospital in Mashhad from 2006 to 2015 using competing risk models.
Materials and Methods: Patients with ALL from March 2006 to February 2015 were reviewed retrospectively, yielding 424 children with acute lymphoblastic leukemia. We considered the recurrence of cancer as a main event and death without recurrence as a competing risk. We employed Cox models and sub-distributions by univariate and multivariate analysis. Data analysis was performed using Stata and R softwares.
Results: The event free 5-year survival and the overall 5-year survival rates of all 424 patients were 70.2% and 81.9% respectively. The 5-year cumulative incident probability of recurrence and death prior to recurrence were 12 and 17 percent respectively. Based on the subdistribution models, white blood cells and blood platelets have been known to affect the recurrence of cancer.
Conclusion: Our results showed that Cox and competing risk models have different results to determine the prognosis factors affecting leukemia patients’ survival despite the competing risks. Also subdistribution models reduce the duration of response to therapy and thus reduce the rate of mortality by providing significant health policies.
Dr Javad Shabani, Dr Mitra Hemmati, Dr Mostafa Sedighi,
Volume 32, Issue 152 (6-2024)
Abstract
Background & Objective: Febrile seizure (FS) is the most common childhood seizure disorder that occurs in 3-4% of children .The aim of this study was to determine the effect of intermittent oral anticonvulsant Levetiracetam in prevention of the recurrence of febrile seizure (FS) in children.
Materials & Methods: This a randomized clinical trial study was conducted on 108 children with FS referred to the pediatric department of Mohammad Kermanshahi Hospital in Kermanshah in 2020. Then, eligible patients were divided into intervention (Levetiracetam; n= 72) and control (Acetaminophen; n= 36) groups using balanced block randomization. The intervention group received a dose of 30-60 mg/kg Levetiracetam during the febrile illness for prophylaxis for 9 months. In contrast, in the control group, only acetaminophen was prescribed just to reduce fever. Finally, the number of FS recurrences were studied in two groups. The data were analyzed using SPSS 26.
Results: The mean (±S.D) age were 2.37 (±1.01) vs. 2.30 (±0.95) years in the intervention and control groups; respectively. The number (%) of boys in the two groups under study was 39 (54.1) and 19 (52.7), respectively. The mean time to first seizure recurrence after the intervention was significantly longer in the intervention group (5.70 ± 0.82 months) than in the control group (2.32 ± 0.75 months) (P-Value<0.05). Also, the mean number of recurrences of FS in the intervention group (2.25 ± 0.80) was significantly lower than the control group (4.13 ± 0.79) (P-Value<0.05).
Conclusion: The administration of oral anticonvulsant Levetiracetam may be effective in the reduction of the recurrences of FS, however, detailed studies in this field is recommended.
