Background and Objective: An optimal regimen for treatment of Helicobacter pylori should have high efficacy, tolerable side effects, easy administration and should be economical. Intensive efforts are being made to identify such an optimal regimen, but there are many obstacles hindering the achievement of this goal. This study aimed at comparing the rate of HP eradication by examining quadruple regimens in dyspeptic patients. Materials and Methods: In this open-label randomized clinical trial, 270 patients with positive Urease test were randomly assigned into four groups to receive one of the following treatment protocols. ( group A: omeprazole+ amoxicillin+ bismuth subcitrate+clarithromycin for 2 weeks (73 patients), group B: omeprazole+tetracycline+bismuth subcitrate+metronidazole for 2 weeks (46 patients), group C: omeprazole+amoxicillin+bismuth subcitrate+furazolidone for 2 weeks (64 patients), groupD: omeprazole+amoxicillin+bismuth subcitrate+furazolidone/metronidazole interchangeably each one for one week (87 patients). Six weeks after the treatment, the compliance, eradication and complication rates were evaluated in each group. Results: Helicobacter pylori eradication rates were, 96.3%, 87%, 79.7%, and 79.3 % in groups A, B, C and D respectively (p=0.506). The overall complication rate was 37%, 63%, 32.8% and 28.7% in groups A, B, C and D respectively. This rate was significantly higher in group B than other groups (p=0.01). The compliance rate was “complete”, ‘good” or “poor”. Accordingly the compliance rate in group A was 83.6%, 11% and 5.5%, in group B, 87%, 6.5% and 6.5%, in group C. 90.6%, 4.7% and 4.7%, and in group D 86.2%, 11.5% and 2.3%, respectively (p=0.683). Abdominal pain and vomiting was significantly more frequent in groups B and C compared to the other groups. The other complications were not significantly different in the groups. Conclusion: The rate of compliance and HP eradication was similar in quadruple regimens however, due to difference in the rate of complications, regimens of groups A or D are recommended.

Background and Objective: Type 2 diabetes is a metabolic disease which could be prevented using a healthy lifestyle. Non-adherence to treatment regimens in diabetes is still a public health problem, globally. This study was conducted to determine the treatment regimens adherence in Type2 diabetes in Zanjan, 2015.
Materials and Methods: A cross-sectional study was conducted on 385 Type 2 diabetes patients. Data was collected using International Physical Activity Questionnaire (IPAQ), and researcher-made questionnaire for diet and drug adherence. The validity and reliability of questionnaires were assessed in good level, through conducting a pilot study. The data was analyzed using SPSS.
Results: The analysis was conducted on 385 patients who had the mean age of 54.9 years. The majority of patients were female (56.4%) and married (80.5%). Most of patients were non-adherent to treatment regimens recommendations (76.9% for physical activity, 50.4% for diet, and 52.5% for medication). A significant association was found among gender, employment status, underlying disease and educational level with non-adherent patients to physical activity recommendations (P<0.05). A significant association was also not found between marital status and diet recommendations (P<0.05). The level of HbA₁C was significantly associated with self-reported adherence to the treatment Regimens (P<0.05).
Conclusion: There was a very low adherence with treatment regimens recommendations. Therefore necessary strategies are necessary to prevent severe complications of diabetes and achieve a better control.