Volume 19, Issue 74 (3-2011)                   J Adv Med Biomed Res 2011, 19(74): 1-8 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Naghibi T, Hossein Khan Z, Shamloo N, Taghizadeh A, Dobakhti F. Evaluation of a Correlation between the Time of Low Dose Fentanyl Injection and Hemodynamic Responses during Tracheal Intubation. J Adv Med Biomed Res 2011; 19 (74) :1-8
URL: http://journal.zums.ac.ir/article-1-1415-en.html
1- Dept. of Anesthesiology, Zanjan University of Medical Sciences, Zanjan, Iran , tnaghibi@zums.ac.ir
2- Dept. of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran
3- Dept. of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran
4- School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract:   (161043 Views)

Background and Objective: This clinical trial was conducted to evaluate optimal time of injection of a small dose of fentanyl during anesthetic induction to attenuate circulatory responses to laryngoscopy and tracheal intubation.
Materials and Methods: 120 patients who had enrolled in this clinical trial, with ASA physical status of I or II scheduled for the elective surgery. The patients were randomly allocated to five groups. In groups II, III, IV, and V, patients received fentanyl (2 mcg/kg) 1, 3, 5, or 10 min respectively before tracheal intubation. In group I patients did not receive fentanyl and served as the control group. After induction with thiopental and atracorium, an oral tracheal intubation was accomplished in each patient. Changes in each circulatory variable after tracheal intubation were based on the differences between baseline values and values obtained 1 min after intubation.
Results: Increase in postintubation heart rate, diastolic and mean arterial pressure compared with preinduction values in group III was less than the other groups. Increased systolic pressure in group IV was less compared with other groups; but there was not a significant difference between groups III and IV.
Conclusion: The results of our study revealed that the optimal injection time of fentanyl in blunting the circulatory responses to tracheal intubation is 3 min before intubation.

Full-Text [PDF 203 kb]   (159438 Downloads)    
Type of Study: Original Research Article |
Received: 2011/03/8 | Accepted: 2014/06/23 | Published: 2014/06/23

References
1. Joo HS, Salasidis GC, Kataoka MT, Mazer CD, Naik VN. Comparison of bolus remifentanil versus bolus Fentanyl for induction of anesthesia and tracheal intubation in patients with cardiac disease. J Cardiothorac Vasc Anesth. 2004; 18: 263-8. [DOI:10.1053/j.jvca.2004.03.003] [PMID]
2. Abrams JT, Horrow JC, Bennett JA. A primary source of difficult ventilation with sufentanil induction of anesthesia. Anesth Analg. 1996; 83: 629-32. [DOI:10.1213/00000539-199609000-00034] [PMID]
3. Ko SH, Kim DC, Han YJ, Song HS. Small-dose Fentanyl: optimal time of injection for blunting the circulatory responses to tracheal intubation. Anesth Analg. 1998; 86: 658-61. [DOI:10.1213/00000539-199803000-00041]
4. Malde AD, Sarode V. Attenuation of the hemodynamic response to endotracheal intubation: fentanyl versus lignocaine. 2007. Available from: URL: http://www.ispub. com/ journal/the_ internet_journal_of _anesthesiology/ volume12_ number_ 1_1/article. [DOI:10.5580/1f02]
5. Adachi YU, Satomoto M, Higuchi H. Fentanyl attenuates the hemodynamic response to endotracheal intubation more than the response to laryngoscopy. Anesth Analg. 2002; 95: 233-7. [DOI:10.1097/00000539-200207000-00043] [PMID]
6. Kim ST, Shin D, Bae JH, Kang H, Lim SW. A Small dose of Fentanyl used prior to 3 minutes before intubation can reduce the incidence of hypertension and tachycardia. Korean J Anesthesiol. 1999; 37: 769-75. [DOI:10.4097/kjae.1999.37.5.769]
7. Rundshagen I, SchroÈder T, Prichep LS, John ER, Kox WJ. Changes in cortical electrical activity during induction of anesthesia with Thiopental/ Fentanyl and tracheal intubation. A quantitative electroencephalographic analysis. Br J Anaesth. 2004; 92: 33-8. [DOI:10.1093/bja/aeh020] [PMID]
8. Ugur B, Ogurlu M, Gezer E, Nuri Aydin O, Gursoy F. Effects of Esmolol, Lidocaine and Fentanyl on haemodynamic responses to endotracheal intubation. Clinical drug investigation. 2007; 27: 269-77. [DOI:10.2165/00044011-200727040-00006] [PMID]
9. Salihoglu Z, Demiroluk S, Demirkiran F, Kose Y. Comparison of effects of remifentanil, Alfentanil and Fentanyl on cardiovascular responses to tracheal intubation in morbidly obese patients. Eur J Anaesthesiol. 2002; 19: 125-8. [DOI:10.1097/00003643-200202000-00009]
10. Kohli M, Abbas H, Parvez Khan M, Rana SH. Comparison of intubating conditions following Propofol and Succinylcholine with Propofol and Fentanyl. J Anaesth Clin Pharmacol. 2008; 24: 205-9.
11. Abdallah C, Karsli C, Bissonnette B. Fentanyl is more effective than remifentanil at preventing increases in cerebral blood flow velocity during intubation in children. Can J Anaesth. 2002; 49: 1070-5. [DOI:10.1007/BF03017905] [PMID]
12. Dahlgren N, Messeter k. Treatment of stress response to laryngoscopy and intubation with Fentanyl. Anesthesia. 1981; 36: 1022-6. [DOI:10.1111/j.1365-2044.1981.tb08676.x] [PMID]
13. Martin DE, Rosenberg H, Aukburg SJ, et al. Low-dose Fentanyl blunts circulatory responses to tracheal intubation. Anesth Analg. 1982; 61: 680-4. [DOI:10.1213/00000539-198208000-00011]
14. Kautto UM. Effect of combinations of topical anesthesia, Fentanyl, Halothane or N2O on circulatory intubation response in normo- and hypertensive patients. Acta Anesthesiol Scand. 1983; 27: 245-51. [DOI:10.1111/j.1399-6576.1983.tb01945.x] [PMID]
15. Kim H, Kim C, Lee J, Kwon Y, Lee J, Kim D. Effects of Fentanyl and Remifentanil on hemodynamic responses to endotracheal intubation during the induction of anesthesia with Propofol. Korean J Anesthesiol. 2006; 51: 552-7. [DOI:10.4097/kjae.2006.51.5.552]
16. Vellosillo M, García G, Ripoll S, Cotaina A, Alacreu B. Bolus administration of Fentanyl vs continuous perfusion of remifentanil for control of hemodynamic response to laryngoscopy and orotracheal intubation: a randomized double-blind trial. Rev Esp Anestesiol Reanim. 2009; 56: 287-91. [DOI:10.1016/S0034-9356(09)70397-4]
17. Guo-hua Z, Li S. Peri-intubation hemodynamic changes during low dose Fentanyl, remifentanil and sufentanil combined with etomidate for anesthetic induction. Chin Med J. 2009; 122: 2330-4.
18. Kaygusuz K, Gursoy S, Ayan S, Mimaroglu C, Gultekin Y. A comparison of sedation with Dexmedetomidine or Propofol during shockwave lithotripsy: A randomized controlled trial. Anesth Analg. 2008; 106: 114-9. [DOI:10.1213/01.ane.0000296453.75494.64] [PMID]
19. Channaiah VB, Chary K, Vlk JL, Wang Y, Chandra S.B.C. Low-dose Fentanyl: hemodynamic response to endotracheal intubation in normotensive patients. Arch Med Sci. 2008; 4: 293-9.
20. Yang QY, Xue FS, Liao X, Liu H, Luo M. Comparison of bolus remifentanil versus bolus Fentanyl for blunting cardiovascular intubation responses in children: a randomized, double-blind study. Chin Med J. 2009; 122: 44-50.

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb