Volume 19, Issue 77 (6-2011)                   J Adv Med Biomed Res 2011, 19(77): 22-30 | Back to browse issues page

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Ghodrati S, Hormati A, Mousavinasab S N, Afifian M. Comparison of FEV1 and PEF Values in Cough Variant Asthma During Methacholine Challenge Test. J Adv Med Biomed Res 2011; 19 (77) :22-30
URL: http://journal.zums.ac.ir/article-1-1654-en.html
Comparison of FEV1 and PEF Values in Cough Variant Asthma During Methacholine Challenge Test
Samad Ghodrati1 , Ahmad Hormati *2 , Seyed Nourdin Mousavinasab3 , Mahboubeh Afifian4
1- Dept. of Internal Medicin, Vali-e-asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
2- Dept. of Internal Medicine,Vali-e-asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran , hormatia@yahoo.com
3- Dept. of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4- Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (167461 Views)

Background and Objective: Asthma is one of the most common chronic diseases with an increasing prevalence. The cough variant of asthma (CVA) is a latent form of the disease. The aim of this study is to compare the decreasing rates of FEV1 and PEF during the methacholine challenge test.
Materials and Methods: In this study, we tested a total of 120 patients (14-65 years old), whom were referred to the respiratory clinic with complaints of chronic cough, using normal chest and sinus x-ray and spirometry. Also other causes of chronic cough were rulled out. Spirometry and Peak Flowmetry were done during the methacholine challenge test, then FEV1 and PEF were recorded.
Results: From 120 patients, 47 patients (39.2%) were male and 73 (60.8%) were female. Thirty three (27.5%) patients showed a ≥ 20% decrease in FEV1, while 35 patients (29.2%) had a ≥ 20% decrease in PEFp. Decreasing values of FEV1 and PEFp with r=0.49 and P-value<0.0001 were significant. Normalization for age, sex, and occupation shows that these factors have no effects on the decrease observed for FEV1 and PEFp.
Conclusion: Based on the correlation ratio for PEFp in comparison with spirometry’s FEV1, we suggest using peak flowmetry instead of spirometry for diagnosing CVA. According on the ROC_curve, we recommend a ≥ 15.5% decrease in the level of PEFp with 79% sensitivity and 69% specificity.

Keywords: Asthma, CVA, FEV1, PEF, Methacholine
Full-Text [PDF 250 kb]   (161109 Downloads)    
Type of Study: Original Research Article |
Received: 2011/11/17 | Accepted: 2014/06/22 | Published: 2014/06/22
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