Background and Objective: HG is a severe form of expectancy nausea and vomiting, occurring in 0/5 to 2% of the expectancies. The etiology of HG is unknown, though hormonal stimuli, and psychologic predisposition are attributable to the condition. Recent studies suggest a relationship between HG and H.pylori infection. The aim of this study was to investigate the  relationship between HG and H.pylori infection.
Material and Methods: Forty pregnant women with HG (Treatment group) and forty asymptomatic pregnant women (control group) were assigned into the research from April  to August 2006. Specific serum immunoglobulin G (IgG) for H.pylori was assayed by ELISA. The data was analyzed using SPSS software, Chi-Square and T-test.
Results: Out of 40 pregnant women with HG 25 individuals (62/5%) were found to have serologically positive H.pylori, whereas in asymptomatic pregnant women 19 (47.5%) individuals were positive, which shows no significant difference between H.Pylori infection with HG (P=0.178). No significant difference was observed between positive H.pylori and the number of pregnancy, body mass index (BMI), and duration of  hospital stay.
Conclusion: Since HG has a multifactorial etiology and with regard to high prevalenve of H pylori in our country, research studies with higher sample sizes and utilization of more sensitive diagnostic methods for the detection of active H pylori is recommended.