1. Pecorino L. Molecular biology of cancer: mechanisms, targets, and therapeutics: Oxford university press; 2012.
2. Umar A, Dunn BK, Greenwald P. Future directions in cancer prevention. Nature Rev Cancer. 2012; 12: 835-48. [
DOI:10.1038/nrc3397] [
PMID]
3. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA: a cancer journal for clinicians. 2013; 63: 11-30. [
DOI:10.3322/caac.21166] [
PMID]
4. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature medicine. 1995; 1: 27-30. [
DOI:10.1038/nm0195-27] [
PMID]
5. Penn JS. Retinal and choroidal angiogenesis: Springer Science & Business Media; 2008. [
DOI:10.1007/978-1-4020-6780-8]
6. Ferrara N. The role of vascular endothelial growth factor in pathological angiogenesis. BreastCancer Res Treat. 1995; 36: 127-37. [
DOI:10.1007/BF00666035] [
PMID]
7. Gasparini G, Harris AL. Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. Journal of clinical oncology. 1995; 13: 765-82. [
DOI:10.1200/JCO.1995.13.3.765] [
PMID]
8. Rössler J, Lagodny J. Blood and lymph vessels in embryonic tumors. Hematological Oncology. 2005; 23: 94-101. [
DOI:10.1002/hon.756] [
PMID]
9. Green DR. Means to an end: apoptosis and other cell death mechanisms: Cold Spring Harbor Laboratory Press; 2011.
10. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001; 411: 342-8. [
DOI:10.1038/35077213] [
PMID]
11. He B, Lu N, Zhou Z. Cellular and nuclear degradation during apoptosis. Current opinion in cell biology. 2009; 21: 900-12. [
DOI:10.1016/j.ceb.2009.08.008] [
PMID] [
PMCID]
12. Suen D-F, Norris KL, Youle RJ. Mitochondrial dynamics and apoptosis. Genes & development. 2008; 22: 1577-90. [
DOI:10.1101/gad.1658508] [
PMID] [
PMCID]
13. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific journal of tropical biomedicine. 2013; 3: 337-52. [
DOI:10.1016/S2221-1691(13)60075-1]
14. Al-Bukhari M, Sahi A-B. The collection of authentic sayings of Prophet Mohammad (peace be upon him), division 71 on medicine. Hilal Yayinlari, Ankara, Turkey. 1976.
15. Khare CP. Indian medicinal plants: an illustrated dictionary: Springer Science & Business Media; 2007. [
DOI:10.1007/978-0-387-70638-2] [
PMCID]
16. Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA. Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. J Ayub Med Coll Abbottabad. 2008; 20: 25-7.
17. Bita A, Rosu A, Calina D, et al. An alternative treatment for candida infections with Nigella sativa extracts. Europ J Hosp Pharm. 2012; 19: 162. [
DOI:10.1136/ejhpharm-2012-000074.203]
18. Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, Khan HA. Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritisin Wistar rats. Chemico Biol Interact. 2012; 197: 40-6. [
DOI:10.1016/j.cbi.2012.03.003] [
PMID]
19. Abdelmeguid NE, Fakhoury R, Kamal SM, Al Wafai RJ. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β‐cells of streptozotocin‐induced diabetic rats. J Diabetes. 2010; 2: 256-66. [
DOI:10.1111/j.1753-0407.2010.00091.x] [
PMID]
20. Salem M, Alenzi F, Attia W. Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro. Br J Biomed Sci. 2011; 68: 131-9. [
DOI:10.1080/09674845.2011.11730340] [
PMID]
21. Alemi M, Sabouni F, Sanjarian F, Haghbeen K, Ansari S. Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content. AAPS PharmSci Tech. 2013; 14: 160-7. [
DOI:10.1208/s12249-012-9899-8] [
PMID] [
PMCID]
22. Ng WK, Saiful Yazan L, Yap LH, et al. Thymoquinone-Loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa). Biomed Res Int. 2015; 2015. [
DOI:10.1155/2015/263131] [
PMID] [
PMCID]
23. Ismail AFH, Doolaanea AA, Mohamed F, Mansor NI, Shafri MAM, Yusof FA. Method development and validation using UV spectrophotometry for Nigella sativa oil microparticles quantification. 2015. [
DOI:10.7324/JAPS.2015.50915]
24. Gerlier D, Thomasset N. Use of MTT colorimetric assay to measure cell activation. J Immunol Method. 1986; 94: 57-63. [
DOI:10.1016/0022-1759(86)90215-2]
25. Worthen DR, Ghosheh OA, Crooks P. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Res. 1997; 18: 1527-32.
26. Swamy S, Tan B. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol. 2000; 70: 1-7. [
DOI:10.1016/S0378-8741(98)00241-4]
27. Havlik J, Kokoska L, Vasickova S, Valterova I. Chemical composition of essential oil from the seeds of Nigella arvensis L. and assessment of its actimicrobial activity. Flavour Fragrance J. 2006; 21: 713-7. [
DOI:10.1002/ffj.1713]
28. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011; 144: 646-74. [
DOI:10.1016/j.cell.2011.02.013] [
PMID]
29. AlHossein M, Abusnina A, Achour M, Sharif T, Muller C, Peluso J, et al. Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1. Biochemical Pharmacol. 2010; 79: 1251-60. [
DOI:10.1016/j.bcp.2009.12.015] [
PMID]
30. Gali-Muhtasib H, Diab-Assaf M, Boltze C, et al. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol. 2004; 25: 857-66.
31. El‐Mahdy MA, Zhu Q, Wang QE, Wani G, Wani AA. Thymoquinone induces apoptosis through activation of caspase‐8 and mitochondrial events in p53‐null myeloblastic leukemia HL‐60 cells. Int J Cancer. 2005; 117: 409-17. [
DOI:10.1002/ijc.21205] [
PMID]
32. Fidler IJ. The pathogenesis of cancer metastasis: the'seed and soil'hypothesis revisited. Nature Reviews Cancer. 2003; 3: 453-8. [
DOI:10.1038/nrc1098] [
PMID]
33. Paramasivam A, Kalaimangai M, Sambantham S, Anandan B, Jayaraman G. Anti-angiogenic activity of thymoquinone by the down-regulation of VEGF using zebrafish (Danio rerio) model. Biomedicine Prevent Nut. 2012; 2:169-73. [
DOI:10.1016/j.bionut.2012.03.011]
34. Paramasivam A, Raghunandhakumar S, Sambantham S, et al. In vitro anticancer and anti-angiogenic effects of thymoquinone in mouse neuroblastoma cells (Neuro-2a). Biomed Prevent Nut. 2012; 2: 283-6. [
DOI:10.1016/j.bionut.2012.04.004]
35. Ting fang Yi, Cho S-G, Yi Z, et al. Thymoquinone inhibi ts tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Molecular Cancer Therap. 2008; 7: 1789-96. [
DOI:10.1158/1535-7163.MCT-08-0124] [
PMID] [
PMCID]
36. Kaur R, Kapoor K, Kaur H. Plants as a source of anticancer agents. J Nat Prod Plant Resour. 2011; 1: 119-24.
37. Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol. 2005; 100: 72-9. [
DOI:10.1016/j.jep.2005.05.011] [
PMID]
38. Hosseinimehr SJ. A review of preventive and therapeutic effects of curcumin in patients with cancer. J Clin Excellence. 2014; 2: 50-63.