Volume 26, Issue 114 (3-2018)                   J Adv Med Biomed Res 2018, 26(114): 40-50 | Back to browse issues page

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Azima S, Houshyar S, Motamedi far M, Kaviani M, Zare N. The Effect of Vaginal Probiotic Capsule On Vaginal Colonization and Treatment Results in Patients with Vulvar and Vaginal Candidiasis. J Adv Med Biomed Res 2018; 26 (114) :40-50
URL: http://journal.zums.ac.ir/article-1-4959-en.html
The Effect of Vaginal Probiotic Capsule On Vaginal Colonization and Treatment Results in Patients with Vulvar and Vaginal Candidiasis
Sara Azima *1 , Somayeh Houshyar2 , Mohammad Motamedi far3 , Masoumeh Kaviani4 , Najaf Zare5
1- Dept Midwifery, Faculty of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran , azimas@sums.ac.ir
2- Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
3- AIDS Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- Dept Midwifery, Faculty of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
5- Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (166987 Views)

Background and Objective: Generally, 75% of women experience vaginal candidiasis at least once in their lifetime. This study aimed to determine the effect of lactobacillus rhamnosus vaginal probiotic capsule on vaginal colonization and treatment results after treating vulvar and vaginal candidiasis.
Materials and Methods: This double-blind clinical trial was conducted in 58 women suffering from vulvar and vaginal candidiasis (based on swab cultures). After treating the patients with clotrimazole 2% vaginal cream, the samples were randomly assigned to probiotic (n=28) and placebo (n=30) groups. While first group took lactobacillus rhamnosus vaginal probiotic capsules twice a day for one week, the second group used vaginal placebo capsules. The patients were examined regarding swab cultures, vaginal lactobacillus colonization, vaginal pH, and clinical symptoms of vulvar and vaginal candidiasis 2-5 days before and 1 month after taking the capsules. Then, the data were fed to SPSS and analyzed using Chi-square, Fisher’s exact test, repeated measures ANOVA, and post-hoc test.
Results: The results showed no significant difference between the two groups concerning the results of fungal culture. Moreover, despite the increase in vaginal lactobacillus colonization in the probiotic group, no significant difference was found between the two groups at different time periods (p=0.255). The results also showed no significant difference between the two groups regarding the mean change of vaginal pH at different time periods (p=0.480).
Conclusion: It seems that using vaginal lactobacillus rhamnosus probiotic capsules was somewhat effective in vaginal lactobacilli colonization in patients with vaginal candidiasis. However, it was not effective in pH changes and treatment results.

Keywords: Lactobacillus rhamnosus, Probiotics, vulvar and vaginal candidiasis, Colonization
Full-Text [PDF 3073 kb]   (156505 Downloads)    
Type of Study: Clinical Trials |
Received: 2017/12/17 | Accepted: 2017/12/17 | Published: 2017/12/17
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