Volume 26, Issue 117 (9-2018)                   J Adv Med Biomed Res 2018, 26(117): 138-144 | Back to browse issues page

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Keilha M, Khorshidi M, Shamsipour E, Navid S. Isolation of Nocardia cyriacigeorgica from Patient Suspected to Tuberculosis. J Adv Med Biomed Res 2018; 26 (117) :138-144
URL: http://journal.zums.ac.ir/article-1-5414-en.html
Isolation of Nocardia cyriacigeorgica from Patient Suspected to Tuberculosis
Masoud Keilha1 , Mahdi Khorshidi1 , Ezzat Shamsipour2 , Sepehr Navid * 3
1- Dept. of Microbiology and Virology, Faculty of Medicine, University of Medical Sciences, Isfahan, Iran.
2- Dept. of Infectious Diseases, Hajar Hospital, Shahrekord, Iran
3- Dept. of Microbiology and Virology, Faculty of Medicine, University of Medical Sciences, Isfahan, Iran. , : Sepehr_2006_70@yahoo.com
Abstract:   (149690 Views)

Nocardia are gram-positive and partially acid-fast bacteria with saprophytic lives in the environment. These groups of bacteria are able to enter the human body through traumatic inhalation and may consequently cause Nocardiosis infections.
Case Presentation: A 32-year-old man was referred to Al-Zahra Hospital with symptoms such as fever, gradual weight loss, and persistent coughing. First, the patient was speculated to have Tuberculosis, but Mycobacterium tuberculosis was not isolated in any sputum samples. Ultimately, a broncho-alveolar lavage sample was acquired from the patient and according to the patient's clinical presentation and microbial assessments, the cause of illness was found to be Nocardia cyriacigeorgica.
Conclusion: According to this report, Nocardiosis infections may occur in immune-compromised patients and even healthy individuals. Given the similarities between the clinical manifestations and radiological findings of Tuberculosis and Nocardia pulmonary infections, medical laboratories should identify Nocardial infections in suspected TB patients.

Keywords: Nocardia cyriacigeorgica, Isolation methods, Antimicrobial susceptibility tests
Full-Text [PDF 1759 kb]   (155748 Downloads)    
Type of Study: Original Article |
Received: 2018/11/14 | Accepted: 2018/11/14 | Published: 2018/11/14
References
1. Brown-Elliott BA, Brown JM, Conville PS, Wallace RJ. Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy. Clin Microb Rev. 2006; 19: 259-82. [DOI:10.1128/CMR.19.2.259-282.2006] [PMID] [PMCID]
2. Wang HK, Sheng WH, Hung CC, et al. Clinical characteristics, microbiology, and outcomes for patients with lung and disseminated nocardiosis in a tertiary hospital. J Formosan Med Assoc. 2015; 114: 742-9. [DOI:10.1016/j.jfma.2013.07.017] [PMID]
3. Ercibengoa M, Pérez-Trallero E, Marimón JM. Autochthonous Nocardia cerradoensis infection in humans, Spain, 2011 and 2014. Emerg Infect Dis. 2016; 22: 109. [DOI:10.3201/eid2201.150771] [PMID] [PMCID]
4. Fleetwood IG, Embil JM, Ross IB. Nocardia asteroides cerebral abscess in immunocompetent hosts: report of three cases and review of surgical recommendations. Surg Neurol. 2000; 53: 605-10. [DOI:10.1016/S0090-3019(00)00242-1]
5. Salehipour M, Zaker Bostanabad S, Rezaee S, Hashemi-Shahraki A. Species spectrum of pathogenic Nocardia isolated from patients. New Cell Molec Biotedn J. 2016; 6: 75-84.
6. Schlaberg R, Huard RC, Della-Latta P. Nocardia cyriacigeorgica, an emerging pathogen in the United States. J Clin Microbiol. 2008; 46: 265-73. [DOI:10.1128/JCM.00937-07] [PMID] [PMCID]
7. Yassin A, Rainey F, Steiner U. Nocardia cyriacigeorgici sp. nov. Int J System Evolunt Microb. 2001; 51: 1419-23. [DOI:10.1099/00207713-51-4-1419] [PMID]
8. Cargill JS, Boyd GJ, Weightman NC. Nocardia cyriacigeorgica: a case of endocarditis with disseminated soft-tissue infection. J Med Microbiol. 2010; 59: 224-30. [DOI:10.1099/jmm.0.011593-0] [PMID]
9. Lalitha P, Srinivasan M, Rajaraman R, et al. Nocardia keratitis: clinical course and effect of corticosteroids. Am J Ophthalmol. 2012; 154: 934-9. e1. [DOI:10.1016/j.ajo.2012.06.001] [PMID] [PMCID]
10. Menkü A, Kurtsoy A, Tucer B, Yıldız O, Akdemir H. Nocardia brain abscess mimicking brain tumour in immunocompetent patients: report of two cases and review of the literature. Acta Neurochirurgica. 2004; 146: 411-4. [DOI:10.1007/s00701-004-0215-6] [PMID]
11. Thirouvengadame S, Muthusamy S, Balaji VK, Easow JM. Unfolding of a Clinically Suspected Case of Pulmonary Tuberculosis. J Clin Diagn Res. 2017; 11: 1-3. [DOI:10.7860/JCDR/2017/25788.10404] [PMID] [PMCID]
12. Eshraghi SS, Bafghi MF, Ghafouri A, et al. Isolation and identification of Nocardia asteroids complex isolated from thigh abscess in a patient with Behçet's syndrome: the first report from Iran. Tehran Univ Med Sci J. 2013; 71: 476-749.
13. Zaker Bostanabad S, Hashemi-Shahraki A, Heidarieh P, Sheikhi N, Sharifi A, Seyri Fouron Abad M. Charactrization and isolation of Nocardia from clinical sample Patient suspected to active tuberculosis. New Cell Molee Biotechnal J. 2014; 4: 19-23. [DOI:10.5899/2014/jgmi-00014]
14. Kageyama A, Hoshino Y, Yazawa K, et al. Nocardia cyriacigeorgica is a significant pathogen responsible for nocardiosis in Japan and Thailand. Mycopathologia. 2005; 160: 15-9. [DOI:10.1007/s11046-005-3050-2] [PMID]
15. Riviere F, Billhot M, Soler C, Vaylet F, Margery J. Pulmonary nocardiosis in immunocompetent patients: can COPD be the only risk factor? Europ Respirat Rev. 2011; 20: 210-2. [DOI:10.1183/09059180.00002211] [PMID]
16. Garcia-Bellmunt L, Sibila O, Solanes I, Sanchez-Reus F, Plaza V. Pulmonary nocardiosis in patients with COPD: characteristics and prognostic factors. Arch Bronconeumología (English Edition). 2012; 48: 280-5. [DOI:10.1016/j.arbr.2012.06.006]
17. Chavez TT, Fraser SL, Kassop D, Bowden III LP, Skidmore PJ. Disseminated Nocardia cyriacigeorgica presenting as right lung abscess and skin nodule. Mili Med. 2011; 176: 586-8. [DOI:10.7205/MILMED-D-10-00346] [PMID]
18. Abu-Gazala M, Engel A, Stern A, Guralnik L. An unusual case of nocardiosis presented as a mediastinal mass in an immunocompetent patient. Am J Respirat Crit Care Med. 2014; 189: 492-3. [DOI:10.1164/rccm.201308-1546LE] [PMID]
19. Fujita T, Ikari J, Watanabe A, Tatsumi K. Clinical characteristics of pulmonary nocardiosis in immunocompetent patients. J Infect Chemother. 2016; 22: 738-43. [DOI:10.1016/j.jiac.2016.08.004] [PMID]
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