Volume 29, Issue 135 (July & August 2021)                   J Adv Med Biomed Res 2021, 29(135): 197-205 | Back to browse issues page

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Zangouie N, Akhiani O, Ravaei H, Beladian-Behbahan S, Javdan G. Nano-Seleniumoxide nanoparticles affect lipid peroxidation and tissue total antioxidant capacity (TAC) in skin injury. J Adv Med Biomed Res 2021; 29 (135) :197-205
URL: http://journal.zums.ac.ir/article-1-6061-en.html
Nano-Seleniumoxide nanoparticles affect lipid peroxidation and tissue total antioxidant capacity (TAC) in skin injury
Nasim Zangouie1 , Omid Akhiani2 , Hooman Ravaei3 , Seyed-Ehsan Beladian-Behbahan4 , Gholamali Javdan *5
1- Pharmaceutical Sciences Branch, Tehran Islamic Azad University, Tehran, Iran
2- Dept. of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
3- Young Researchers and Elite Club, Ardabil Branch, Islamic Azad University, Ardabil, Iran
4- Dept. of Health and Social Medicine, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
5- Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran , Javdan.gholamali@gmail.com
Abstract:   (136373 Views)

Background and Objective: Skin flaps in the distal region lose their tissue because of impaired perfusion, which is strongly due to the ischemia-reperfusion injury (IRI) and oxidative stress (OS). Reducing reactive oxygen species (ROS) and increasing antioxidant capacity are the most important approaches to preserve flaps. Given the antioxidant effects of selenium, it is expected to be effective in enhancing flap survival.
Materials and Methods: In this survey, 30 rats were divided into 3 groups of 10: 1) sham group (incision of the flap margin without elevation of the bed), 2) flap surgery group (incision and elevation of the skin from bed+plastic film placement under the flap), and 3) flap surgery+nano-selenium oxide treatment (incision and elevation of the skin from bed+plastic film placement under the flap+nano-selenium oxide 25 mg/kg intraperitoneally).
On the seventh day after flap surgery, the flap necrosis percentage, malondialdehyde (MDA) level, and superoxide dismutase (SOD) activity were measured.
Results: Flap necrosis and the level of MDA significantly increased in the flap surgery group and decreased in the nano-selenium oxide-treated group (P<0.05). SOD activity decreased in the flap surgery group and increased in the nano-selenium oxide-treated group (P<0.05).
Conclusion: The results of this study showed that treatment with nano-selenium oxide reduced flap tissue necrosis and lipid peroxidation significantly; it also increased SOD activity. Therefore, the survival of the flap and its efficacy increased.

Keywords: Skin flap, Nano-selenium oxide, Oxidative stress, Ischemia-reperfusion injury, Malondialdehyde
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✅The results of this study showed that treatment with nano-selenium oxide reduced flap tissue necrosis and lipid peroxidation significantly; it also increased SOD activity. Therefore, the survival of the flap and its efficacy increased.


Type of Study: Original Research Article | Subject: Medical Biology
Received: 2020/06/13 | Accepted: 2021/02/9 | Published: 2021/02/28
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