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Volume 29, Issue 136 (September & October 2021)
J Adv Med Biomed Res 2021, 29(136): 286-292 |
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Naderi Nabi B, Saberi A, Bakhshayesh Eghbali B, Hosseininezhad M, Biazar G, Abbasi Malekabadi A et al . Efficacy and Safety of TENS and Duloxetine in Patients with Painful Diabetic Neuropathy: A Single Blind Randomized Clinical Trial. J Adv Med Biomed Res 2021; 29 (136) :286-292
URL: http://journal.zums.ac.ir/article-1-6193-en.html
URL: http://journal.zums.ac.ir/article-1-6193-en.html
Bahram Naderi Nabi1 
, Alia Saberi2 , Babak Bakhshayesh Eghbali3 , Mozaffar Hosseininezhad * 4, Gelareh Biazar5 , Amir Abbasi Malekabadi5 , Ladan Mirmansouri6
, Alia Saberi2 , Babak Bakhshayesh Eghbali3 , Mozaffar Hosseininezhad * 4, Gelareh Biazar5 , Amir Abbasi Malekabadi5 , Ladan Mirmansouri6
1- Anesthesiology Research Center, Department of Anesthesiology, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran
2- Dept. of Anesthesiology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3- Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran
4- Dept. of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran ,dr.hoseinnezhad2020@gmail.com
5- Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran
6- Student Research Committee, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
2- Dept. of Anesthesiology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3- Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran
4- Dept. of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran ,
5- Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran
6- Student Research Committee, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
Abstract: (135078 Views)
Background and Objective: Both duloxetine (DLX) and transcutaneous electrical nerve stimulation (TENS) are recommended as safe and effective treatments for diabetic peripheral neuropathic pain. However, these methods have not been compared. This study aimed to compare the efficacy of treatment by DLX and TENS in diabetic neuropathy pain relief.
Materials and Methods: This survey was performed on 60 eligible diabetic patients randomly divided into two groups of DLX (20, 40, and 60 mg/day for weeks 1, 2, and 3-12, respectively), and TENS (20 min,80 HZ, 50 Amp, 0.2 ms Square pulses 2-3 times sensory threshold). The participants were evaluated according to the numerical rating scale (NRS) after four and twelve weeks of treatment. Moreover, adverse drug reactions were documented during the study period.
Results: Baseline demographic data had no significant difference between the two groups (P≥0.05). The average NRS scores were significantly lower in the DLX group in both measurement times. At the end of weeks four (P=0.01) and 12 (P=0.001), the trend of changes was significant from baseline to the third month (P=0.0001). No patient in the TENS group reported any side effects, while 18% did in the DLX group.
Conclusion: We found that both DLX and TENS were effective and safe for the management of painful diabetic neuropathy. The DLX seemed to be better, compared to TENS. However, in some conditions, such as drug intolerance or contraindication for medications, TENS could be a proper intervention.
Materials and Methods: This survey was performed on 60 eligible diabetic patients randomly divided into two groups of DLX (20, 40, and 60 mg/day for weeks 1, 2, and 3-12, respectively), and TENS (20 min,80 HZ, 50 Amp, 0.2 ms Square pulses 2-3 times sensory threshold). The participants were evaluated according to the numerical rating scale (NRS) after four and twelve weeks of treatment. Moreover, adverse drug reactions were documented during the study period.
Results: Baseline demographic data had no significant difference between the two groups (P≥0.05). The average NRS scores were significantly lower in the DLX group in both measurement times. At the end of weeks four (P=0.01) and 12 (P=0.001), the trend of changes was significant from baseline to the third month (P=0.0001). No patient in the TENS group reported any side effects, while 18% did in the DLX group.
Conclusion: We found that both DLX and TENS were effective and safe for the management of painful diabetic neuropathy. The DLX seemed to be better, compared to TENS. However, in some conditions, such as drug intolerance or contraindication for medications, TENS could be a proper intervention.
Type of Study: Clinical Trials |
Subject:
Health improvement strategies
Received: 2020/09/1 | Accepted: 2020/12/28 | Published: 2021/04/4
Received: 2020/09/1 | Accepted: 2020/12/28 | Published: 2021/04/4
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