Volume 31, Issue 145 (March & April 2023)                   J Adv Med Biomed Res 2023, 31(145): 197-203 | Back to browse issues page

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Asadi R, Raouf Sarshoori J, Ghorbani M, Mofid M. Evaluation of the Effect of Boron on Histopathological Changes of Atherosclerotic Plaque in Aortic Arch and Lipid Profiles in Hyperlipidemic New Zealand Male Rabbits. J Adv Med Biomed Res 2023; 31 (145) :197-203
URL: http://journal.zums.ac.ir/article-1-6836-en.html
Evaluation of the Effect of Boron on Histopathological Changes of Atherosclerotic Plaque in Aortic Arch and Lipid Profiles in Hyperlipidemic New Zealand Male Rabbits
Robabeh Asadi1 , Javad Raouf Sarshoori * 2, Maryam Ghorbani3 , Mahmood Mofid1
1- Dept. of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
2- Dept. of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran , raoufsar@gmail.com
3- Dept. of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract:   (10990 Views)

Background and Objective: Cardiovascular diseases are the most important causes of death worldwide. Atherosclerosis, as a common form of cardiovascular disease, tends to involve specific areas of the circulatory system. Boron has anti-inflammatory and antioxidant properties with potential beneficial effects. In this study, we investigated the effect of Boron on histopathological changes of atherosclerotic plaque and lipid profile in hyperlipidemic rabbits.
Materials and Methods: Male rabbits in five groups of control, sham, hyperlipidemia, treatment 1 and treatment 2 were fed on high fat diet (1% cholesterol). Treatment groups received Boron, 4 mg / kg, on the first and 20th days of experiment. Animals’ weights were measured on days 1, 21 and 60. Plasma levels of Cholesterol, LDL, HDL and TG were measured by photometric method. After 60 days, Sudan IV staining method was used for macroscopic study. Hematoxylin-eosin and Masson’s trichrome staining method were performed for quantitative analysis.
Results: Animals in the control and sham groups showed no significant change in serum lipid profile with no atherosclerotic plaque in aortic vessels. In the hyperlipidemia group, significant alterations in lipid profile and presence of atheroma plaques were detected. In animals receiving Boron as a protective agent, atheroma plaques were significantly less (p <0.05). This was confirmed by quantitative analysis.
Conclusion: Boron ameliorates the development and progression of atherosclerotic plaques. Boron can be used alone or in combination with other drugs as anti-atherosclerotic treatment.

Keywords: Atherosclerosis, Boron, Hyperlipidemia, Atheroma plaques, Lipid profile
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✅Boron ameliorates the development and progression of atherosclerotic plaques. Boron can be used alone or in combination with other drugs as anti-atherosclerotic treatment.


Type of Study: Original Article | Subject: Pharmacology
Received: 2022/01/12 | Accepted: 2022/08/20 | Published: 2023/03/13
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