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Volume 31, Issue 147 (July & August 2023)
J Adv Med Biomed Res 2023, 31(147): 364-371 |
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Karami A, Fallahpour F, Motamed N, Jafari M R. Evaluation of the Effects of Vitamin C in Prognosis of Patients with Sepsis in Zanjan Vali- e-Asr Hospital in 2020. J Adv Med Biomed Res 2023; 31 (147) :364-371
URL: http://journal.zums.ac.ir/article-1-6980-en.html
URL: http://journal.zums.ac.ir/article-1-6980-en.html
1- Dept. of Infectious Diseases, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2- Dept. of Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
3- Dept. of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran ,jafari@zums.ac.ir & jafarimrj@yahoo.com
2- Dept. of Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
3- Dept. of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran ,
Abstract: (1230 Views)
Background and Objective: Regarding the high prevalence of sepsis, it is important to discover methods to control this condition. Valuable effect of vitamin C in vasopressin synthesis is demonstrated, moreover, its antioxidant effect reduces vascular infiltration. Therefore, the beneficial effects of vitamin C in prognosis of the patients who have been admitted to Vali-e- Asr hospital in Zanjan, Iran with the diagnosis of sepsis have been evaluated.
Materials and Methods: This cross sectional study was planned on patients with sepsis who have been admitted to the infectious ward of Vali-e-Asr hospital in Zanjan. Patients with sepsis above 18 years old from June to March 2020 have been included in this study. Data of patients whom have received intravenous vitamin C, 25 mg/kg/24h for 4 days, and patients without reception vitamin C was collected from their files. Their demographic, clinical and para clinical information were collected, then the information was analyzed.
Results: 54 patients (26 received vitamin C and 28 did not receive vitamin C) were enrolled in this study. Considering that the two groups were matched from the beginning of the study, no statistically significant difference was found between the two groups of patients in demographic characteristics. Furthermore, there were no significant differences in the sepsis induced complications, e.g. laboratory findings, mean days of hospitalization in ICU and SOFA score.
Conclusion: Our findings demonstrated that no clear statistically significant difference was found between the two groups of control and vitamin C received groups; nonetheless for precise conclusion more studies with larger groups are required.
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✅ Our findings demonstrated that no clear statistically significant difference was found between the two groups of control and vitamin C received groups; nonetheless for precise conclusion more studies with larger groups are required.
Type of Study: Clinical Trials |
Subject:
Clinical medicine
Received: 2022/11/17 | Accepted: 2023/03/25 | Published: 2023/09/27
Received: 2022/11/17 | Accepted: 2023/03/25 | Published: 2023/09/27
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