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Volume 32, Issue 152 (May & June 2024)
J Adv Med Biomed Res 2024, 32(152): 174-184 |
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Bahrami A, Nikoomanesh F, Dehghani H, Aramjoo H, A. Ferns G. Curcumin Ameliorates Depression, and Anxiety in Patients with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blinded Placebo-Controlled Trial. J Adv Med Biomed Res 2024; 32 (152) :174-184
URL: http://journal.zums.ac.ir/article-1-7456-en.html
URL: http://journal.zums.ac.ir/article-1-7456-en.html
1- , bahramiaf@mums.ac.ir
Abstract: (47 Views)
Background & Objective: Premenstrual syndrome (PMS) and primary dysmenorrhea (PD) are gynecological conditions that are associated with psychological and mood disorders. This study assessed the effects of curcumin, a natural polyphenol, on depression, anxiety, stress and quality of life (QL) in woman with PMS and PD.
Materials & Methods: The study was undertaken in 128 women who were randomised to treatment with either curcumin (n=64) or placebo (n=64) groups. Each subject received one capsules (500 mg of curcuminoids plus 5 mg piperine, or a placebo, plus 5 mg piperine) daily, for 3 successive menstrual cycles. Psychological status and QL were assessed using Depression, Anxiety, Stress Scales-21 (DASS-21) and the Short Form-12 (SF-12) questionnaires respectively.
Results: Overall scores as well as the mental health domain of the SF-12 improved significantly after curcumin supplementation (P<0.05). In addition, curcumin decreased significantly (P<0.05) all of the DASS-21 domains (depression, anxiety and stress). Significant differences were also found between the two groups for the DASS-21 domains, SF-12 mental health (total) and overall scores (P<0.05).
Conclusion: Curcuminoids may be useful as a natural, widely accessible therapeutic option for the management of the psychological impact of PMS and PD, and improve the QL of women with these conditions.
Materials & Methods: The study was undertaken in 128 women who were randomised to treatment with either curcumin (n=64) or placebo (n=64) groups. Each subject received one capsules (500 mg of curcuminoids plus 5 mg piperine, or a placebo, plus 5 mg piperine) daily, for 3 successive menstrual cycles. Psychological status and QL were assessed using Depression, Anxiety, Stress Scales-21 (DASS-21) and the Short Form-12 (SF-12) questionnaires respectively.
Results: Overall scores as well as the mental health domain of the SF-12 improved significantly after curcumin supplementation (P<0.05). In addition, curcumin decreased significantly (P<0.05) all of the DASS-21 domains (depression, anxiety and stress). Significant differences were also found between the two groups for the DASS-21 domains, SF-12 mental health (total) and overall scores (P<0.05).
Conclusion: Curcuminoids may be useful as a natural, widely accessible therapeutic option for the management of the psychological impact of PMS and PD, and improve the QL of women with these conditions.
Type of Study: Original Article |
Subject:
Clinical medicine
Received: 2024/03/12 | Accepted: 2024/08/18 | Published: 2024/06/21
Received: 2024/03/12 | Accepted: 2024/08/18 | Published: 2024/06/21
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