Volume 19, Issue 77 (6-2011)                   J Adv Med Biomed Res 2011, 19(77): 22-30 | Back to browse issues page

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Ghodrati S, Hormati A, Mousavinasab S N, Afifian M. Comparison of FEV1 and PEF Values in Cough Variant Asthma During Methacholine Challenge Test. J Adv Med Biomed Res 2011; 19 (77) :22-30
URL: http://journal.zums.ac.ir/article-1-1654-en.html
Comparison of FEV1 and PEF Values in Cough Variant Asthma During Methacholine Challenge Test
Samad Ghodrati1 , Ahmad Hormati *2 , Seyed Nourdin Mousavinasab3 , Mahboubeh Afifian4
1- Dept. of Internal Medicin, Vali-e-asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
2- Dept. of Internal Medicine,Vali-e-asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran , hormatia@yahoo.com
3- Dept. of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4- Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (167462 Views)

Background and Objective: Asthma is one of the most common chronic diseases with an increasing prevalence. The cough variant of asthma (CVA) is a latent form of the disease. The aim of this study is to compare the decreasing rates of FEV1 and PEF during the methacholine challenge test.
Materials and Methods: In this study, we tested a total of 120 patients (14-65 years old), whom were referred to the respiratory clinic with complaints of chronic cough, using normal chest and sinus x-ray and spirometry. Also other causes of chronic cough were rulled out. Spirometry and Peak Flowmetry were done during the methacholine challenge test, then FEV1 and PEF were recorded.
Results: From 120 patients, 47 patients (39.2%) were male and 73 (60.8%) were female. Thirty three (27.5%) patients showed a ≥ 20% decrease in FEV1, while 35 patients (29.2%) had a ≥ 20% decrease in PEFp. Decreasing values of FEV1 and PEFp with r=0.49 and P-value<0.0001 were significant. Normalization for age, sex, and occupation shows that these factors have no effects on the decrease observed for FEV1 and PEFp.
Conclusion: Based on the correlation ratio for PEFp in comparison with spirometry’s FEV1, we suggest using peak flowmetry instead of spirometry for diagnosing CVA. According on the ROC_curve, we recommend a ≥ 15.5% decrease in the level of PEFp with 79% sensitivity and 69% specificity.

Keywords: Asthma, CVA, FEV1, PEF, Methacholine
Full-Text [PDF 250 kb]   (161110 Downloads)    
Type of Study: Original Research Article |
Received: 2011/11/17 | Accepted: 2014/06/22 | Published: 2014/06/22
References
1. Fauci A, Brauwald E, kasper D, et al. Harrison's principles of internal medicine. Chicago: Mc Graw-Hill; 2008.
2. Goldman L, Ausiello D. Cecil Medicine. Assesment of dynamic function. New York: Saunders; 2007.
3. Fishman A, Elias J, Senior R. Fishman's pulmonary diseases and disorders, New York: Mc Graw-Hill; 2008.
4. Boushey J, Corry D, Fahy J, Burchard E, Woodruff P. Murray & Nadel's textbook of respiratory medicine. Philadelphia: Saunders; 2005.
5. ATS committee on proficiency standards for clinical pulmonary function laboratories. Guidelines for methacholine and exercise challenge testing-1999. Am J Respir Crit Care Med. 2000; 161: 309-29. [DOI:10.1164/ajrccm.161.1.ats11-99] [PMID]
6. Nemati A, Moghimi A, Rahmati m. A Comparison between forced expiratory volume in the first second (FEV1) and peak expiratory flow rate (PEFR) after respiratory challenge tests in young males with dyspnea. J Iran Uni Med Sci. 2006; 51: 205-14.
7. Giannini D, Paggiaro PL, Moscato G, et al. Comparison between PEF and FEV1 during bronchoconstriction induced by different stimuli. J Asthma. 1997: 34: 105-11. [DOI:10.3109/02770909709075654] [PMID]
8. Linna O. Sensitivity of PEFR for diagnosing bronchial obstruction on methacholine inhalation challeng in school-aged asthmatic children. Acta Paediatr. 1998; 87: 635-7. [DOI:10.1111/j.1651-2227.1998.tb01522.x] [PMID]
9. Gharagozlou M, Kompani F, Movahedi M. Comparison between peak expiratory flow rate and forced expiratory volume in one second in theevaluation of children suspected to have asthma. Iranian J Allergy, Asthma Immunol. 2004; 3: 21-5.
10. Kang H, Koh YY, Young Yoo Y, et al. Maximal airway response to methacholine in cough-variant asthma comparison with classic asthma and its relationship to peak expiratory flow variability. Chest. 2005; 128: 3881-7. [DOI:10.1378/chest.128.6.3881] [PMID]
11. Leroyer C, Perfetti L, Trudeau C, L'archevêque J, Chan-Yeung M, Malo J. Comparison of serial monitoring of peak expiratory flow and FEV1 in the diagnosis of occupational asthma. Am J Respir Crit Care Med. 1998; 158: 827-32. [DOI:10.1164/ajrccm.158.3.9707093] [PMID]
12. Koh YY, Kang H, Yoo Y. Peak expiratory flow variability and exercise responsiveness in methacholine-hyperresponsive adolescents with asthma remission. J Asthma. 2005: 42; 17-23. [DOI:10.1081/JAS-200028014] [PMID]
13. Prieto L, Gutierrez V, Berto Jm. Relationship between airway responsiveness and peak expiratory flow variability in subjects with allergic rhinitis. Annals Allergy Asthma Immunol. 1995: 75: 273-9.
14. Jindal SL, Aggarwal AN, Gupta D. Diurnal variability of peak expiratory flow. J Asthma. 2002: 39; 363-73. [DOI:10.1081/JAS-120004029] [PMID]
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