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Volume 10, Issue 41 (12-2002)
J Adv Med Biomed Res 2002, 10(41): 15-23 |
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Moghaddamnia A, Bisheh Sari N. Protective Effect Of Alcohol On Muscle Paralysis Induced By Atracorium. J Adv Med Biomed Res 2002; 10 (41) :15-23
URL: http://journal.zums.ac.ir/article-1-334-en.html
URL: http://journal.zums.ac.ir/article-1-334-en.html
Abstract: (150510 Views)
Introduction: Regarding the side effects of muscle relaxants especially non - depolarizing agents, this study was done to determine the protective effect of alcohol on muscle paralysis induced by atracurium in preparation of isolated chicken biventer cervices muscle.
Materials and Methods: This experimental study was performed on two groups of chicken biventer cervices muscles. In each group, 6 chickens were recruited. After inserting the muscles in an organ bath containing Tirod physiologic solution and oxygen at 37°c, atracurium was introduced to the first group. A combination of alcohol and atracurium was added to the second group. The percentage of muscle paralysis and duration of contraction in each group were then registered. A student t-test was performed for analysis of the data.
Results: Percent of muscle paralysis followed by atracurium introduction in chick biventer cervices muscle was decreased in the presence of ethanol (p<0.01). Duration of paralysis was decreased also in the group receiving ethanol compared with the group receiving atracurium alone (p<0.01).
Conclusion: Results suggested that ethanol with possible presynaptic and postsynaptic effects can protect the muscle against the paralysis induced by atracurium.
Materials and Methods: This experimental study was performed on two groups of chicken biventer cervices muscles. In each group, 6 chickens were recruited. After inserting the muscles in an organ bath containing Tirod physiologic solution and oxygen at 37°c, atracurium was introduced to the first group. A combination of alcohol and atracurium was added to the second group. The percentage of muscle paralysis and duration of contraction in each group were then registered. A student t-test was performed for analysis of the data.
Results: Percent of muscle paralysis followed by atracurium introduction in chick biventer cervices muscle was decreased in the presence of ethanol (p<0.01). Duration of paralysis was decreased also in the group receiving ethanol compared with the group receiving atracurium alone (p<0.01).
Conclusion: Results suggested that ethanol with possible presynaptic and postsynaptic effects can protect the muscle against the paralysis induced by atracurium.
Type of Study: Original Research Article |
Received: 2008/09/28 | Accepted: 2017/06/18 | Published: 2017/06/18
Received: 2008/09/28 | Accepted: 2017/06/18 | Published: 2017/06/18
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