Sat, Jun 7, 2025
[Archive]
Volume 19, Issue 76 (5-2011)
J Adv Med Biomed Res 2011, 19(76): 58-65 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Torabi S Z, Abbaszadeh R, Ahmadiafshar A. The Effect of Oral Zinc Sulfate on the Management of Acute Gastroenteritis in Children. J Adv Med Biomed Res 2011; 19 (76) :58-65
URL: http://journal.zums.ac.ir/article-1-1571-en.html
URL: http://journal.zums.ac.ir/article-1-1571-en.html
1- Aayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran , drztorabi@yahoo.com
2- Aayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
2- Aayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract: (193630 Views)
Background and Objective: Gastroenteritis is a major cause of mortality and morbidity among infants and children around the world. Zinc with increasing the absorbent capacity of enteric villous cells and decreasing the enteric gram negative bacteria and blocking chloride excretion leads to cell healing and helps diarrhea to resolve faster. The present study evaluates the effect of oral zinc sulfate syrup on infants of the city of
Zanjan- Iran.
Materials and Methods: In this randomized double blind trial, 400 hospitalized infants (age range of 6 to 24 months) with acute gastroenteritis were divided into two equal groups. The case group received 20 mg of daily oral zinc sulfate; whereas control group took the placebo. Data was gathered with questionnaires and recorded precisely over 10 days and then analyzed with independent statistical t-test and Mann-Whitney
U-test.
Results: Findings indicated that the frequency of diarrhea in the case group was less than the control group and weight gain after 10 days in the case group was more than the control group(P<0.0001). Meanwhile, there was no significant difference in hospitalization period and duration of diarrhea.
Conclusion: The results of this study pointed out that there is a meaningful relation between times of
diarrhea and weight gain in infants with acute gastroenteritis receiving oral zinc sulfate. Thus, prescription of zinc sulfate for infants with acute diarrhea for a period of 10 to 14 days is suggested.
Type of Study: Original Research Article |
Received: 2011/08/24 | Accepted: 2014/06/22 | Published: 2014/06/22
Received: 2011/08/24 | Accepted: 2014/06/22 | Published: 2014/06/22
References
1. Shamir R, Makhoul IR, Etzioni A. Shehadeh N. Evaluation of a diet containing probiotics and zinc for the treatment of mild diarrheal in children younger than one year of age. J Am Coll Nutr. 2005; 24: 370-5. [DOI:10.1080/07315724.2005.10719487] [PMID]
2. Sullivan PB. Nutritional management of acute diarrhea. Nutr. 1998; 14: 758-62. [DOI:10.1016/S0899-9007(98)00078-1]
3. Bhutta ZA, Bird SM, Black RE, et al. Zinc Investigators Collaborative Group. Therapeutic effects of oral zinc in acute and persistent diar-roea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr. 2000; 72: 1516-22. [DOI:10.1093/ajcn/72.6.1516] [PMID]
4. American Academy of Pediatrics. Provision-al Committee on Quality Improvement, Sub-committee on Acute Gastroenteritis. Practice parameters: the management of acute gastroen-teritis in young children. Pediatrics. 1996; 97: 424-33.
5. Walker SJA, Sanghu BK, Isolauri E, et al. Guidelines prepared by the ESPGAN working group on acute diarrhoea. Recommendations for feeling in childhood gastroenteritis. J Pedi-atr Gastroenterol Nutr. 1997; 24: 619-20. [DOI:10.1097/00005176-199705000-00024] [PMID]
6. Salvatore S, Hauser B, Devreker T, et al. Probiotics and zinc in acute infectious gastroen-teritis in children: are they effective. Nutr. 2007; 23: 498-506. [DOI:10.1016/j.nut.2007.03.008] [PMID]
7. Baqui AH, Black RE, EL Arifeen S, et al. Effect of Zind suplementation started during diarrhea on morbidity and mortality in Bangla-deshi children: community randomized trial. BMJ. 2002; 325; 1059-66. [DOI:10.1136/bmj.325.7372.1059] [PMID] [PMCID]
8. Brooks WA, Santosham M, Roy SK, et al. Efficacy of zinc in young infants with acute watery diarrhea. AM J Clin Nutr. 2005; 82: 605-10. [DOI:10.1093/ajcn/82.3.605]
9. Sachdev HP, Mittal NK, Mittal SK, Yadav HS. A controlled trial on utility of oral zinc supplementation in acute dehydrating in diar-rhea infants. J Pediatr Gastroenterol Nutr. 1998; 7: 877-81. [DOI:10.1097/00005176-198811000-00015] [PMID]
10. Faruque AS, Mahalanabis D, Haque SS, Fuchs GJ, Habte D. Double blind, randomized, controlled trial of zinc or vitamin A supplemen-tation in young children with acute diarrhea. Acta paediatr. 1999; 88: 154-60. [DOI:10.1111/j.1651-2227.1999.tb01074.x]
11. Roy SK, Tomkins AM , Mahalanabis D, et al. Impact of zinc supplementation on persistentdiarrhoea in malnourished Bangladeshi chil-dren. Acta Paediatr. 1998; 87: 1235-9. [DOI:10.1111/j.1651-2227.1998.tb00943.x] [PMID]
12. Bhatnagar S, Bahl R, Sharma PK, Kumar GT, Saxena SK, Bhan MK. Zinc with oral rehy-dration therapy stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. J Pediatr Gastroenterol Nutr. 2004; 38:34- 40. [DOI:10.1097/00005176-200401000-00010] [PMID]
13. Garcia-Naveiro R, Udall JRJ. Maldigestion and malabsorption. In: Wyllie R, Hyams JS. Pediatric gastrointestinal and liver disease. saunders Elsevier, 2006.
14. Winqertzahn MA, Rehman KU, Altaf W, Wapnir RA. Zinc as a potential enteroprotector in oral rehydration solution: its role in nitric oxide metabolism. Pediatr Res. 2003; 53: 434-9. [DOI:10.1203/01.PDR.0000049465.73687.4D] [PMID]
15. Hoque KM, Brinder HJ. Zinc in the treat-ment of acute diarrhea:Current status and as-sessment. Gastroenterol. 2006; 130: 2201-5 [DOI:10.1053/j.gastro.2006.02.062] [PMID]
16. Hoque KM, Rjender VM, Binder HJ. Zinc inhibits camp stimulated chlorine secretion via basolateral K-channel blockade in rat ileumam.J Physiol Gastrointest Liver Physiol. 2005; 288: 956-63. [DOI:10.1152/ajpgi.00441.2004] [PMID]
17. Raqib R, Roy SK, Rahman MJ, et al. Effi-cacy of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis. Am J Clin Nutr. 2004: 79: 444-50 [DOI:10.1093/ajcn/79.3.444] [PMID]
18. Sazawal S, Dhriqra U, Dhriqra P, et al. Effectivity of fortified milk on morbidity in young children in north India: community based,randomized double masked, placebo controlled trial. BMJ. 2007; 334: 140. [DOI:10.1136/bmj.39035.482396.55] [PMID] [PMCID]
19. Awathi S, Inclen Childnet. Zinc effect fordiarrhea (IC-ZED) Group. Zinc supplementation in acute diarrhea is accepted, does not interfere with oral rehydration reduces the use of other medications: a randomized trial in five coun-tries. J Pediatr Gastroenterol Nutr. 2006; 42: 253-5. [DOI:10.1097/01.mpg.0000189340.00516.30] [PMID]
20. Bhandari N, Mazumder S, Taneja S,et al. A pilot test of the addition of zinc to the current case management package of diarrhea in a pri-mary health care setting. J Pediatr Gastroenter-ol Nutr. 2005; 41: 685-7. [DOI:10.1097/01.mpg.0000182799.69675.92] [PMID]
21. Strand TA, Adhikari RK, Chandyo RK, Sharma PR, Sommerfelt H.Predictors of plasma zinc concentration in children with acute diar-rhea. Am J Clin Nutr. 2004; 79: 451-6. [DOI:10.1093/ajcn/79.3.451] [PMID]
22. Black RE. Zinc deficiency, infectious dis-eases and mortality in the developing world. J Nutr. 2003; 5133: 1485s-9s. [DOI:10.1093/jn/133.5.1485S] [PMID]
23. Bhandari N, Bahl R, Taneja S. Substantial reduction in severe diarrhea morbidity by daily zinc supplementation in young north Indianchildren. Pediatrics. 2002; 109: e86. [DOI:10.1542/peds.109.6.e86] [PMID]
24. Nasrin D, Larson CP, Sultana S, Khan TU. Acceptance of And adherence to dispersible zinc tablets in the treatment of acute childhood diarrhea. J Health Popul Nutr. 2005; 23: 215-21.
25. Boran P, Tokuc G, Vagas E, Okten S, Gokduman MK. Impact of zinc supplementa-tion in children with diarrhea in Turkey. Arch dis child. 2006; 91: 296-9. [DOI:10.1136/adc.2005.079939] [PMID] [PMCID]
26. Bahl R, Bhandari N, Saskena M. Efficacy of zinc fortified oral rehydration solution in 6-35 month old children with acute diarrhea. J Pediatr. 2002; 141: 677-82. [DOI:10.1067/mpd.2002.128543] [PMID]
27. Allahverdi Ghorbanivegar A. Impact of zinc supplementation in children with diarrhea in Aligoudarz city. Lorestan Uni Medical Sci J. 2006; 8: 24-35.
28. Shadcam M ,Khosravi H. Efficacy of zinc sulfat in children with diarrhea in Rafsanjan.Rafsanjan Uni Med Sci J. 2008; 5: 47-52.
29. Movahdi Z, Shokrollahi M,Tabraie Y, Ali-pour K. Efficacy of zinc sulfat in children with diarrhea. Ghom Uni Med Sci J. 2008; 2: 33-6.
30. Gotbi N, Hasani S, Gaderi E. Effectiveness of zinc supplementation plus oral rehydration salts for diarrhoea in infants in Gorgan. Gor-gan Uni Med Sci J. 2008; 10: 27-31.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright Policy
