The purpose of this research is to study the effects of streptokinase on complications and mortality in patients suffering from inferior wall infarction associated with right ventricular infarction. To this end, all the patiens with inferior wall infarction who referred to Zanjan Shahid Beheshti Hospital from April 1994 to February 1998 were studied.This research included the patients whose ST segment elevation was more or equal to one mm in V3R and V3R leads. One hundred thirty of them had right ventricular infarction and 37 people of them (28.5%) were treated with streptokinase and 93 (71.5%) of them did not take this drug. Treatment with streptokinase decreased the prevalence of right ventricular and atrial dilatation. After using this drug the rate of prevalence of right bundle branch block shifted from 2.2% to Zero and that of arrhythmias also reduced so that the prevalence of atrioventricular changed from 22.6% to 5.4%.In consequence of taking streptokinase, the prevalence of cardiogenic shock decreased from 7.5% to 2.7%. However, this drug resulted in the increase of cardiogenic shock in the patients with hypertension history after right ventricular infarction. Treatment with streptokinase led to the decrease in the prevalence of post infaction complications in patients with right ventricular infarction. In consequence of taking this drug, the prevalence of only reinfarction and post MI angina as well as intracranial and gastrointestinal hemorrhage increased. Treatment with streptokinase decreased the prevalence of left and right ventricular systolic dysfunction and it increased the prevalence of EF≥55 from 42% to 56.7%. Therefore, taking this drug led to a greater percentage of patients with EF≥55.Treatment with this drug resulted in the decrease of mortality in patients with right ventricular infarction and had no effect on the length of hospitalization.
Type of Study:
Original Research Article |
Received: 2008/11/11 | Accepted: 2001/06/15 | Published: 2001/06/15