Volume 29, Issue 136 (September & October 2021)                   J Adv Med Biomed Res 2021, 29(136): 279-285 | Back to browse issues page

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Mazloomi S, Alizadeh N, Shafiee G, Ghorbani S, Afsharirad M. The Effects of Hypothyroidism on Maternal Health. J Adv Med Biomed Res 2021; 29 (136) :279-285
URL: http://journal.zums.ac.ir/article-1-6183-en.html
The Effects of Hypothyroidism on Maternal Health
Sahar Mazloomi1 , Narges Alizadeh2 , Gholamreza Shafiee * 3, Somayeh Ghorbani4 , Massoume Afsharirad5
1- Dept. of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Dept.of Obstetrics and Gynecology, Bijar Imam Hossein Hospital, Kurdistan University of Medical Sciences, Kurdistan, Iran
3- Dept. of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , g.r_shafiee@yahoo.com
4- Dept. of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
5- Dept.of High Risk Pregnancy, Bijar Imam Hossein Hospital, Kurdistan University of Medical Sciences, Kurdistan, Iran
Abstract:   (129907 Views)

Background and Objective: Hypothyroidism leads to an increased risk of overweight and obesity. This study examined the effect of weight gain caused by hypothyroidism on maternal health (hypertension, gestational diabetes, and miscarriage) for the first time.
Materials and Methods: This case-control study consisted of 123 pregnant women with clinical hypothyroidism and 242 non-hypothyroid pregnant women as the control group. National guidelines were used to diagnose hypothyroidism in the first trimester. Body mass index (BMI), thyroid-stimulating hormone level, as well as systolic and diastolic blood pressure (BP) were measured. Moreover, fasting blood sugar was assessed during 24-28 weeks of gestation. Data were analyzed by the Chi-square, Student’s t-distribution, and logistic regression using the SPSS19 software.
Results: We found a significant relationship between BMI and hypothyroidism in pregnant women (P<0.001). Systolic and diastolic BP in the case group were higher in women with BMI≥25 (P=0.017 and P=0.002). Furthermore, diastolic BP had a significant impact on abortion (P=0.018). The rate of abortion increases by 1.042 with 1 mmHg elevation in diastolic BP in pregnant women if the variables maternal age, hypothyroidism, and overweight are constant.
Conclusion: According to the results of the present study, weight gain in women with hypothyroidism can affect the risk of high diastolic BP and abortion.

Keywords: Abortion, Hypertension, Hypothyroidism, Obesity, Overweight
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✅ According to the results of the present study, weight gain in women with hypothyroidism can affect the risk of high diastolic BP and abortion.


Type of Study: Original Article | Subject: Clinical medicine
Received: 2020/08/24 | Accepted: 2021/03/14 | Published: 2021/04/4
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