Volume 30, Issue 139 (March & April 2022)                   J Adv Med Biomed Res 2022, 30(139): 190-195 | Back to browse issues page


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Rajabi-Moghaddam M, Sarparast G, Abbaszadeh H. Bicytopenia Secondary to Autoimmune Myelofibrosis as the First Presentation of an Undiagnosed Systemic Lupus Erythematosus: A Rare Case Report. J Adv Med Biomed Res 2022; 30 (139) :190-195
URL: http://journal.zums.ac.ir/article-1-6278-en.html
1- Dept. of Pathology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
2- Dept. of Hematology and Oncology, Iranmehr Hospital, Birjand University of Medical Sciences, Birjand, Iran
3- Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran , hamidabbaszade@yahoo.com
Abstract:   (93682 Views)

Autoimmune myelofibrosis (AIMF) is considered as an infrequent cause of bone marrow fibrosis (BMF) and a rare complication of systemic lupus erythematosus (SLE). Due to its rarity, it is mistakenly diagnosed as primary myelofibrosis (MF).
We describe the clinicopathologic features of a secondary form of AIMF in a 33- year- old female patient with an undiagnosed SLE which presented with acute bicytopenia. Absence of splenomegaly, leukopenia, anemia, BMF (grade MF-1), and presence of autoantibodies were some of noticeable features. Treatment with corticosteroid led to complete regeneration of the bone marrow and subsequently to an improved hematological status. Six- month follow-up showed that the patient was in good clinical condition.
Identification of AIMF is a diagnostic challenge and pitfall and it is actually a diagnosis of exclusion. It could be the first and only presenting feature of SLE and results in hematologic disturbances. So, we should consider SLE-associated AIMF in the differential diagnosis of pancytopenia.

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 Autoimmune myelofibrosis (AIMF) considered an infrequent cause of bone marrow fibrosis (BMF) and is a rare complication of systemic lupus erythematosus (SLE). Due to its rarity, it is mistakenly diagnosed primary MF. We describe the clinicopathologic features of a secondary form of AIMF in a 33 years old female patient with an undiagnosed SLE which presented with acute bicytopenia


Type of Study: Case Report Article | Subject: Clinical Medicine
Received: 2020/10/27 | Accepted: 2021/03/8 | Published: 2022/01/31

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