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Volume 31, Issue 147 (July & August 2023)
J Adv Med Biomed Res 2023, 31(147): 316-322 |
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Zakerkish M, Ghafuri Z, Kosarian Z, Hessam M, ShaterzadehYazdi M, Rafie S et al . Comparing the Efficacy of Duloxetine with High Tone Power Therapy in Diabetic Peripheral Neuropathic Pain: A Double-Blind Randomized Phase III Clinical Trial. J Adv Med Biomed Res 2023; 31 (147) :316-322
URL: http://journal.zums.ac.ir/article-1-6927-en.html
URL: http://journal.zums.ac.ir/article-1-6927-en.html
Mehrnoosh Zakerkish * 
1, Zohre Ghafuri2 , Zahra Kosarian3 , Masumeh Hessam3 , Mohammadjafar ShaterzadehYazdi3 , Shahram Rafie4 , Seyed Mahmoud Latifi2
1, Zohre Ghafuri2 , Zahra Kosarian3 , Masumeh Hessam3 , Mohammadjafar ShaterzadehYazdi3 , Shahram Rafie4 , Seyed Mahmoud Latifi2
1- Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , mehr.zaker@yahoo.com
2- Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- Dept. of Neurology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,Iran
2- Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- Dept. of Neurology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,Iran
Abstract: (1215 Views)
Background and Objective: Diabetic neuropathy pain is a common pain condition that has a major negative impact on health-related quality of life. However, despite many studies, it remains difficult to treat neuropathic pain. This study aimed to compare the efficacy of duloxetine with high tone power therapy (HTPT) in diabetic peripheral neuropathic pain.
Materials and Methods: The study is a single-centre, phase III clinical trial comparing the effect of HTPT versus treatment with duloxetine in diagnosed diabetic neuropathy patients between October 2019 to December 2020. In the case group, the HTPT was used with a four-second duration for 30 minutes daily. This treatment was continued twice a week for 10 sessions. The control group received duloxetine (30 mg/m2 once a day). The treatment response was assessed based on the VAS score.
Results: The results showed that in both groups, there was a significant reduction in pain severity. In HTPT group, the average pain decreased from 7.36 to 4.6 and in duloxetine group from 7.7 to 4.8. During 8 measurements after the intervention; decrease in VAS score was higher in HTPT group (5.6) than in duloxetine group (6.5) in the first and fourth times after the intervention (P-Value=0.01). Further analysis demonstrated a positive correlation between pain severity and age so that, the pain also increases with advancing age.
Conclusion: The results of the present study showed that both duloxetine and high tone therapies are safe and effective methods for neuropathic pain relief.
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✅ The results of the present study showed that both duloxetine and high tone therapies are safe and effective methods for neuropathic pain relief.
Type of Study: Original Article |
Subject:
Clinical medicine
Received: 2022/10/21 | Accepted: 2023/01/22 | Published: 2023/09/27
Received: 2022/10/21 | Accepted: 2023/01/22 | Published: 2023/09/27
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