Volume 14, Issue 56 (Sep 2006)                   J Adv Med Biomed Res 2006, 14(56): 6-11 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

jafari M R, Tabrizian P, Fekrmandi F, Onsori S. The Antinociceptive effect of Intracerebroventricular injection of Soya oil. J Adv Med Biomed Res 2006; 14 (56) :6-11
URL: http://journal.zums.ac.ir/article-1-111-en.html
Abstract:   (169491 Views)

Background & Objective: Several studies have shown that Soya oil has analgesic effects when it administered orally or injected. Oral administration of Soya oil has antinociceptive effect on bone dysplasia induced pain. Based on previous reports concerning analgesic effect of peripheral administration of Soya oil and the usage of the oil as a solvent or the oil part of emulsions to prepare water-insoluble drugs, we investigated the analgesic effect of intracerebroventricular (i.c.v.) injection of Soya oil.
Materials & Methods: The antinociceptive effects of i.c.v. administration of Soya oil using formalin test have been studied in stereotaxed mice after one week of surgery and insertion of a stainless steel canulla in the right cerebroventricle.
Results: Administration of pure Soya oil induced an antinociceptive effect in mice but the oil did not show any analgesic effects in 10 percent concentration.
Conclusion: The results of this study are in agreement with previous data on analgesic effect of peripheral administration of Soya oil. Therefore, we suggest that minimum concentrations should be used to prepare emulsions with Soya oil for water insoluble drugs in antinociception studies.

Full-Text [PDF 152 kb]   (159566 Downloads)    
Type of Study: Original Research Article |
Received: 2007/11/12 | Accepted: 2014/06/30 | Published: 2014/06/30

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb